Target name

Q14524: Sodium channel protein type 5 subunit alpha


  Protein function

This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant Na(+) channel isoform. This channel is responsible for the initial upstroke of the action potential. Channel inactivation is regulated by intracellular calcium levels.

  Database links

Uniprot primary ID Q14524
PDB ID 4DJC 2L53 4OVN 4JQ0 4DCK 2KBI
DrugBank ID DB00776 DB00564 DB00680 DB00754 DB00750 DB00281 DB00280
BioGrid ID 112236
GuidetoPHARMACOLOGY ID 582
PharmGKB ID PA304
KEGG ID hsa:6331
DIP ID DIP-46144N;DIP-38416N
STRING ID 9606.ENSP00000328968
IntAct ID Q14524
DMDM 215273881
BRENDA
Reactome R-HSA-445095
SignaLink
BioCyc
Entrez Gene (Gene ID) 6331
BindingDB Q14524

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.836 0.014 0.920 0.006 0.878 0.006 0.873 0.009 0.950 0.000 0.758 0.017 Download
Estate fingerprints 0.817 0.013 0.767 0.009 0.792 0.009 0.799 0.011 0.853 0.005 0.585 0.018 Download
MACCS fingerprints 0.854 0.005 0.772 0.009 0.813 0.005 0.822 0.004 0.910 0.000 0.629 0.009 Download
Daylight fingerprints 0.808 0.004 0.848 0.004 0.828 0.004 0.824 0.005 0.889 0.003 0.653 0.007 Download
ECFP2 fingerprints 0.888 0.009 0.904 0.009 0.896 0.007 0.896 0.007 0.960 0.000 0.788 0.014 Download
ECFP4 fingerprints 0.897 0.007 0.931 0.005 0.914 0.005 0.914 0.005 0.970 0.000 0.832 0.006 Download
ECFP6 fingerprints 0.877 0.005 0.975 0.007 0.926 0.005 0.921 0.003 0.978 0.004 0.855 0.008 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
 E-mail: biomed@csu.edu.cn