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E-mail: biomed@csu.edu.cn
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Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein. Isoform 5, isoform 6, isoform 7 and isoform 8 lack the catalytic site and may interfere with the pro-apoptotic activity of the complex.
| Uniprot primary ID | Q14790 |
| PDB ID | 3KJQ 4ZBW 2FUN 4PRZ 4JJ7 1I4E 4PS1 1F9E 2K7Z 1QDU 2C2Z 1QTN 2Y1L 3KJN 3H11 |
| DrugBank ID | |
| BioGrid ID | 107291 |
| GuidetoPHARMACOLOGY ID | 1624 |
| PharmGKB ID | PA26092 |
| KEGG ID | hsa:841 |
| DIP ID | DIP-30915N |
| STRING ID | 9606.ENSP00000351273 |
| IntAct ID | Q14790 |
| DMDM | 2493531 |
| BRENDA | 3.4.22.61 |
| Reactome | R-HSA-933543 R-HSA-3371378 R-HSA-75108 R-HSA-264870 R-HSA-111465 R-HSA-5213460 R-HSA-168638 R-HSA-5218900 R-HSA-69416 R-HSA-75153 R-HSA-140534 R-HSA-2562578 R-HSA-75157 R-HSA-5357786 R-HSA-75158 R-HSA-5660668 |
| SignaLink | Q14790 |
| BioCyc | |
| Entrez Gene (Gene ID) | 841 |
| BindingDB | Q14790 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.931 | 0.003 | 0.967 | 0.005 | 0.949 | 0.003 | 0.945 | 0.005 | 0.984 | 0.005 | 0.895 | 0.005 | Download |
| Estate fingerprints | 0.920 | 0.000 | 0.826 | 0.003 | 0.873 | 0.005 | 0.880 | 0.000 | 0.940 | 0.000 | 0.749 | 0.003 | Download |
| MACCS fingerprints | 0.930 | 0.000 | 0.884 | 0.005 | 0.907 | 0.005 | 0.909 | 0.003 | 0.980 | 0.000 | 0.811 | 0.003 | Download |
| Daylight fingerprints | 0.880 | 0.000 | 0.980 | 0.005 | 0.930 | 0.000 | 0.923 | 0.005 | 0.970 | 0.000 | 0.859 | 0.003 | Download |
| ECFP2 fingerprints | 0.927 | 0.005 | 0.985 | 0.004 | 0.956 | 0.005 | 0.950 | 0.000 | 0.980 | 0.000 | 0.910 | 0.000 | Download |
| ECFP4 fingerprints | 0.926 | 0.005 | 0.994 | 0.000 | 0.960 | 0.000 | 0.960 | 0.000 | 1.000 | 0.000 | 0.926 | 0.005 | Download |
| ECFP6 fingerprints | 0.930 | 0.005 | 1.000 | 0.000 | 0.967 | 0.005 | 0.964 | 0.005 | 0.992 | 0.004 | 0.933 | 0.007 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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