Target name

Q14790: Caspase-8


  Protein function

Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein. Isoform 5, isoform 6, isoform 7 and isoform 8 lack the catalytic site and may interfere with the pro-apoptotic activity of the complex.

  Database links

Uniprot primary ID Q14790
PDB ID 3KJQ 4ZBW 2FUN 4PRZ 4JJ7 1I4E 4PS1 1F9E 2K7Z 1QDU 2C2Z 1QTN 2Y1L 3KJN 3H11
DrugBank ID
BioGrid ID 107291
GuidetoPHARMACOLOGY ID 1624
PharmGKB ID PA26092
KEGG ID hsa:841
DIP ID DIP-30915N
STRING ID 9606.ENSP00000351273
IntAct ID Q14790
DMDM 2493531
BRENDA 3.4.22.61
Reactome R-HSA-933543 R-HSA-3371378 R-HSA-75108 R-HSA-264870 R-HSA-111465 R-HSA-5213460 R-HSA-168638 R-HSA-5218900 R-HSA-69416 R-HSA-75153 R-HSA-140534 R-HSA-2562578 R-HSA-75157 R-HSA-5357786 R-HSA-75158 R-HSA-5660668
SignaLink Q14790
BioCyc
Entrez Gene (Gene ID) 841
BindingDB Q14790

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.931 0.003 0.967 0.005 0.949 0.003 0.945 0.005 0.984 0.005 0.895 0.005 Download
Estate fingerprints 0.920 0.000 0.826 0.003 0.873 0.005 0.880 0.000 0.940 0.000 0.749 0.003 Download
MACCS fingerprints 0.930 0.000 0.884 0.005 0.907 0.005 0.909 0.003 0.980 0.000 0.811 0.003 Download
Daylight fingerprints 0.880 0.000 0.980 0.005 0.930 0.000 0.923 0.005 0.970 0.000 0.859 0.003 Download
ECFP2 fingerprints 0.927 0.005 0.985 0.004 0.956 0.005 0.950 0.000 0.980 0.000 0.910 0.000 Download
ECFP4 fingerprints 0.926 0.005 0.994 0.000 0.960 0.000 0.960 0.000 1.000 0.000 0.926 0.005 Download
ECFP6 fingerprints 0.930 0.005 1.000 0.000 0.967 0.005 0.964 0.005 0.992 0.004 0.933 0.007 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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