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E-mail: biomed@csu.edu.cn
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p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution.
| Uniprot primary ID | Q15078 |
| PDB ID | 1UNH 1H4L 1UNL 3O0G 1UNG |
| DrugBank ID | |
| BioGrid ID | 114376 |
| GuidetoPHARMACOLOGY ID | |
| PharmGKB ID | PA26311 |
| KEGG ID | hsa:8851 |
| DIP ID | DIP-24222N |
| STRING ID | 9606.ENSP00000318486 |
| IntAct ID | Q15078 |
| DMDM | 2498217 |
| BRENDA | |
| Reactome | R-HSA-399956 |
| SignaLink | Q15078 |
| BioCyc | |
| Entrez Gene (Gene ID) | 8851 |
| BindingDB | Q15078 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.792 | 0.009 | 0.994 | 0.000 | 0.893 | 0.005 | 0.881 | 0.007 | 0.980 | 0.000 | 0.802 | 0.009 | Download |
| Estate fingerprints | 0.864 | 0.007 | 0.950 | 0.003 | 0.907 | 0.005 | 0.899 | 0.003 | 0.965 | 0.005 | 0.816 | 0.007 | Download |
| MACCS fingerprints | 0.883 | 0.005 | 0.965 | 0.005 | 0.924 | 0.005 | 0.922 | 0.004 | 0.970 | 0.000 | 0.853 | 0.007 | Download |
| Daylight fingerprints | 0.604 | 0.005 | 0.998 | 0.000 | 0.801 | 0.003 | 0.754 | 0.005 | 0.960 | 0.000 | 0.661 | 0.003 | Download |
| ECFP2 fingerprints | 0.898 | 0.006 | 0.984 | 0.005 | 0.941 | 0.003 | 0.939 | 0.006 | 0.990 | 0.000 | 0.887 | 0.007 | Download |
| ECFP4 fingerprints | 0.912 | 0.006 | 0.994 | 0.000 | 0.953 | 0.005 | 0.952 | 0.004 | 1.000 | 0.000 | 0.911 | 0.006 | Download |
| ECFP6 fingerprints | 0.912 | 0.008 | 0.996 | 0.000 | 0.954 | 0.005 | 0.952 | 0.004 | 0.994 | 0.005 | 0.910 | 0.007 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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