Target name

Q15078: Cyclin-dependent kinase 5 activator 1


  Protein function

p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution.

  Database links

Uniprot primary ID Q15078
PDB ID 1UNH 1H4L 1UNL 3O0G 1UNG
DrugBank ID
BioGrid ID 114376
GuidetoPHARMACOLOGY ID
PharmGKB ID PA26311
KEGG ID hsa:8851
DIP ID DIP-24222N
STRING ID 9606.ENSP00000318486
IntAct ID Q15078
DMDM 2498217
BRENDA
Reactome R-HSA-399956
SignaLink Q15078
BioCyc
Entrez Gene (Gene ID) 8851
BindingDB Q15078

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.792 0.009 0.994 0.000 0.893 0.005 0.881 0.007 0.980 0.000 0.802 0.009 Download
Estate fingerprints 0.864 0.007 0.950 0.003 0.907 0.005 0.899 0.003 0.965 0.005 0.816 0.007 Download
MACCS fingerprints 0.883 0.005 0.965 0.005 0.924 0.005 0.922 0.004 0.970 0.000 0.853 0.007 Download
Daylight fingerprints 0.604 0.005 0.998 0.000 0.801 0.003 0.754 0.005 0.960 0.000 0.661 0.003 Download
ECFP2 fingerprints 0.898 0.006 0.984 0.005 0.941 0.003 0.939 0.006 0.990 0.000 0.887 0.007 Download
ECFP4 fingerprints 0.912 0.006 0.994 0.000 0.953 0.005 0.952 0.004 1.000 0.000 0.911 0.006 Download
ECFP6 fingerprints 0.912 0.008 0.996 0.000 0.954 0.005 0.952 0.004 0.994 0.005 0.910 0.007 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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