Target name

Q15661: Tryptase alpha/beta-1


  Protein function

Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity. Isoform 2 cleaves large substrates, such as fibronectin, more efficiently than isoform 1, but seems less efficient toward small substrates (PubMed:18854315).

  Database links

Uniprot primary ID Q15661
PDB ID 1LTO 4MQA 2ZEC 2ZEB 4A6L 2F9P 2F9O 2F9N 4MPX 4MPU 4MPW 4MPV
DrugBank ID
BioGrid ID 113029
GuidetoPHARMACOLOGY ID 2424
PharmGKB ID PA36698
KEGG ID hsa:7177
DIP ID
STRING ID 9606.ENSP00000343577
IntAct ID Q15661
DMDM 18202508
BRENDA 3.4.21.59
Reactome R-HSA-1592389
SignaLink
BioCyc
Entrez Gene (Gene ID) 7177
BindingDB Q15661

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.802 0.014 0.904 0.005 0.853 0.007 0.845 0.010 0.941 0.003 0.709 0.016 Download
Estate fingerprints 0.973 0.005 0.905 0.003 0.939 0.003 0.940 0.000 0.980 0.000 0.879 0.006 Download
MACCS fingerprints 0.904 0.010 0.894 0.007 0.899 0.006 0.903 0.008 0.969 0.003 0.803 0.013 Download
Daylight fingerprints 0.778 0.004 0.866 0.005 0.822 0.004 0.815 0.005 0.898 0.004 0.650 0.007 Download
ECFP2 fingerprints 0.989 0.003 0.951 0.004 0.970 0.000 0.970 0.000 0.990 0.000 0.937 0.005 Download
ECFP4 fingerprints 0.986 0.005 0.974 0.005 0.980 0.005 0.980 0.005 1.000 0.000 0.956 0.010 Download
ECFP6 fingerprints 0.983 0.005 0.991 0.004 0.987 0.005 0.987 0.005 1.000 0.000 0.972 0.006 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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