Receptor for extracellular ATP > UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response.
| Uniprot primary ID | Q15722 |
| PDB ID | |
| DrugBank ID | |
| BioGrid ID | 107645 |
| GuidetoPHARMACOLOGY ID | 267 |
| PharmGKB ID | PA30476 |
| KEGG ID | hsa:1241 |
| DIP ID | |
| STRING ID | 9606.ENSP00000307445 |
| IntAct ID | Q15722 |
| DMDM | 3041713 |
| BRENDA | |
| Reactome | R-HSA-391906 R-HSA-416476 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 1241 |
| BindingDB | Q15722 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.868 | 0.004 | 0.928 | 0.000 | 0.898 | 0.004 | 0.892 | 0.004 | 0.957 | 0.005 | 0.795 | 0.007 | Download |
| Estate fingerprints | 0.883 | 0.005 | 0.885 | 0.003 | 0.884 | 0.005 | 0.884 | 0.005 | 0.948 | 0.004 | 0.769 | 0.006 | Download |
| MACCS fingerprints | 0.870 | 0.000 | 0.866 | 0.003 | 0.868 | 0.004 | 0.870 | 0.000 | 0.940 | 0.000 | 0.737 | 0.005 | Download |
| Daylight fingerprints | 0.924 | 0.005 | 0.802 | 0.003 | 0.863 | 0.005 | 0.870 | 0.000 | 0.900 | 0.000 | 0.733 | 0.005 | Download |
| ECFP2 fingerprints | 0.949 | 0.003 | 0.947 | 0.000 | 0.948 | 0.004 | 0.948 | 0.004 | 0.990 | 0.000 | 0.890 | 0.005 | Download |
| ECFP4 fingerprints | 0.949 | 0.003 | 0.971 | 0.005 | 0.960 | 0.000 | 0.960 | 0.000 | 0.990 | 0.000 | 0.926 | 0.005 | Download |
| ECFP6 fingerprints | 0.928 | 0.004 | 0.988 | 0.000 | 0.958 | 0.004 | 0.954 | 0.005 | 0.990 | 0.000 | 0.914 | 0.005 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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