Target name

Q15722: Leukotriene B4 receptor 1


  Protein function

Receptor for extracellular ATP > UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response.

  Database links

Uniprot primary ID Q15722
PDB ID
DrugBank ID
BioGrid ID 107645
GuidetoPHARMACOLOGY ID 267
PharmGKB ID PA30476
KEGG ID hsa:1241
DIP ID
STRING ID 9606.ENSP00000307445
IntAct ID Q15722
DMDM 3041713
BRENDA
Reactome R-HSA-391906 R-HSA-416476
SignaLink
BioCyc
Entrez Gene (Gene ID) 1241
BindingDB Q15722

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.868 0.004 0.928 0.000 0.898 0.004 0.892 0.004 0.957 0.005 0.795 0.007 Download
Estate fingerprints 0.883 0.005 0.885 0.003 0.884 0.005 0.884 0.005 0.948 0.004 0.769 0.006 Download
MACCS fingerprints 0.870 0.000 0.866 0.003 0.868 0.004 0.870 0.000 0.940 0.000 0.737 0.005 Download
Daylight fingerprints 0.924 0.005 0.802 0.003 0.863 0.005 0.870 0.000 0.900 0.000 0.733 0.005 Download
ECFP2 fingerprints 0.949 0.003 0.947 0.000 0.948 0.004 0.948 0.004 0.990 0.000 0.890 0.005 Download
ECFP4 fingerprints 0.949 0.003 0.971 0.005 0.960 0.000 0.960 0.000 0.990 0.000 0.926 0.005 Download
ECFP6 fingerprints 0.928 0.004 0.988 0.000 0.958 0.004 0.954 0.005 0.990 0.000 0.914 0.005 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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