Target name

Q15761: Neuropeptide Y receptor type 5


  Protein function

Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders.

  Database links

Uniprot primary ID Q15761
PDB ID 2HE6
DrugBank ID
BioGrid ID 110949
GuidetoPHARMACOLOGY ID 308
PharmGKB ID PA31742
KEGG ID hsa:4889
DIP ID
STRING ID 9606.ENSP00000339377
IntAct ID Q15761
DMDM 215274093
BRENDA
Reactome R-HSA-418594 R-HSA-375276
SignaLink
BioCyc
Entrez Gene (Gene ID) 4889
BindingDB

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.798 0.004 0.912 0.004 0.855 0.005 0.847 0.005 0.940 0.000 0.715 0.005 Download
Estate fingerprints 0.811 0.003 0.709 0.003 0.760 0.000 0.771 0.003 0.820 0.000 0.527 0.005 Download
MACCS fingerprints 0.809 0.003 0.751 0.003 0.780 0.000 0.790 0.000 0.846 0.005 0.567 0.005 Download
Daylight fingerprints 0.750 0.000 0.910 0.004 0.830 0.000 0.817 0.005 0.870 0.000 0.668 0.004 Download
ECFP2 fingerprints 0.905 0.005 0.913 0.003 0.909 0.003 0.909 0.003 0.960 0.000 0.814 0.005 Download
ECFP4 fingerprints 0.921 0.003 0.979 0.000 0.950 0.000 0.950 0.000 0.980 0.000 0.902 0.004 Download
ECFP6 fingerprints 0.900 0.000 0.990 0.000 0.945 0.005 0.941 0.003 0.980 0.000 0.893 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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