Target name

Q16602: Calcitonin gene-related peptide type 1 receptor


  Protein function

Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3 (By similarity). Receptor for adrenomedullin together with RAMP2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

  Database links

Uniprot primary ID Q16602
PDB ID 3N7R 3N7S 3N7P 3AQF 4RWG 4RWF
DrugBank ID
BioGrid ID 115498
GuidetoPHARMACOLOGY ID
PharmGKB ID PA26033
KEGG ID hsa:10203
DIP ID DIP-37674N
STRING ID 9606.ENSP00000376177
IntAct ID Q16602
DMDM 226693507
BRENDA
Reactome R-HSA-418555 R-HSA-419812
SignaLink
BioCyc
Entrez Gene (Gene ID) 10203
BindingDB Q16602

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.966 0.005 0.968 0.005 0.967 0.005 0.967 0.005 0.990 0.000 0.930 0.000 Download
Estate fingerprints 0.929 0.003 0.851 0.005 0.890 0.000 0.895 0.005 0.960 0.000 0.785 0.005 Download
MACCS fingerprints 0.946 0.005 0.914 0.000 0.930 0.000 0.932 0.004 0.990 0.000 0.869 0.003 Download
Daylight fingerprints 0.960 0.000 0.878 0.004 0.919 0.003 0.920 0.000 0.940 0.000 0.839 0.003 Download
ECFP2 fingerprints 0.990 0.000 0.970 0.003 0.980 0.000 0.980 0.000 1.000 0.000 0.960 0.000 Download
ECFP4 fingerprints 0.990 0.000 1.000 0.000 0.998 0.004 0.998 0.004 1.000 0.000 0.990 0.000 Download
ECFP6 fingerprints 0.988 0.004 0.998 0.000 0.993 0.005 0.993 0.005 1.000 0.000 0.988 0.004 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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