Target name

Q16790: Carbonic anhydrase 9


  Protein function

Reversible hydration of carbon dioxide. Participates in pH regulation. May be involved in the control of cell proliferation and transformation. Appears to be a novel specific biomarker for a cervical neoplasia.

  Database links

Uniprot primary ID Q16790
PDB ID 2HKF 3IAI
DrugBank ID DB00774 DB00562 DB00909 DB00999
BioGrid ID 107223
GuidetoPHARMACOLOGY ID
PharmGKB ID PA25998
KEGG ID hsa:768
DIP ID DIP-48973N
STRING ID 9606.ENSP00000367608
IntAct ID
DMDM 83300925
BRENDA 4.2.1.1
Reactome R-HSA-1475029 R-HSA-1234158
SignaLink
BioCyc
Entrez Gene (Gene ID) 768
BindingDB Q16790

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.921 0.003 0.909 0.005 0.915 0.005 0.915 0.005 0.970 0.000 0.831 0.003 Download
Estate fingerprints 0.886 0.005 0.914 0.000 0.900 0.000 0.900 0.000 0.960 0.000 0.800 0.000 Download
MACCS fingerprints 0.830 0.000 0.872 0.000 0.851 0.003 0.850 0.000 0.950 0.000 0.710 0.000 Download
Daylight fingerprints 0.691 0.003 0.829 0.000 0.760 0.000 0.744 0.005 0.810 0.000 0.530 0.000 Download
ECFP2 fingerprints 0.961 0.003 0.957 0.000 0.959 0.003 0.959 0.003 0.990 0.000 0.915 0.005 Download
ECFP4 fingerprints 0.959 0.003 0.961 0.000 0.960 0.000 0.960 0.000 0.990 0.000 0.923 0.005 Download
ECFP6 fingerprints 0.942 0.004 0.978 0.000 0.960 0.000 0.959 0.003 0.990 0.000 0.913 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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