Target name

Q494W8: CHRNA7-FAM7A fusion protein


  Protein function

acetylcholine-gated channel complex, neuron projection, synapse, acetylcholine binding, cation transmembrane transport, neurological system process, regulation of membrane potential, signal transduction, synaptic transmission, cholinergic

  Database links

Uniprot primary ID Q494W8
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID
PharmGKB ID PA26483
KEGG ID hsa:89832
DIP ID
STRING ID 9606.ENSP00000299847
IntAct ID
DMDM 91208254
BRENDA
Reactome
SignaLink
BioCyc
Entrez Gene (Gene ID) 89832
BindingDB Q494W8

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.839 0.007 0.835 0.005 0.837 0.005 0.837 0.005 0.920 0.000 0.674 0.005 Download
Estate fingerprints 0.846 0.005 0.790 0.003 0.818 0.004 0.823 0.005 0.880 0.000 0.637 0.007 Download
MACCS fingerprints 0.857 0.005 0.729 0.004 0.793 0.005 0.807 0.005 0.880 0.000 0.592 0.004 Download
Daylight fingerprints 0.800 0.005 0.760 0.005 0.780 0.000 0.780 0.000 0.810 0.000 0.554 0.005 Download
ECFP2 fingerprints 0.879 0.006 0.919 0.007 0.899 0.003 0.898 0.004 0.953 0.005 0.799 0.006 Download
ECFP4 fingerprints 0.882 0.004 0.966 0.005 0.924 0.005 0.920 0.005 0.972 0.004 0.850 0.008 Download
ECFP6 fingerprints 0.873 0.005 0.973 0.000 0.923 0.005 0.920 0.000 0.970 0.000 0.853 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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 E-mail: biomed@csu.edu.cn