Target name

Q5RAG0: Histone deacetylase 1


  Protein function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation.

  Database links

Uniprot primary ID Q5RAG0
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID
PharmGKB ID
KEGG ID pon:100172663
DIP ID
STRING ID 9601.ENSPPYP00000001838
IntAct ID
DMDM
BRENDA
Reactome
SignaLink
BioCyc
Entrez Gene (Gene ID) 100172663
BindingDB Q5RAG0

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.850 0.000 0.910 0.005 0.880 0.000 0.873 0.005 0.950 0.000 0.756 0.005 Download
Estate fingerprints 0.880 0.000 0.780 0.000 0.830 0.000 0.838 0.004 0.920 0.000 0.660 0.000 Download
MACCS fingerprints 0.837 0.005 0.883 0.003 0.860 0.000 0.855 0.005 0.940 0.000 0.718 0.004 Download
Daylight fingerprints 0.707 0.005 0.767 0.000 0.737 0.005 0.729 0.003 0.800 0.000 0.471 0.003 Download
ECFP2 fingerprints 0.966 0.005 0.934 0.003 0.950 0.000 0.950 0.000 0.990 0.000 0.894 0.005 Download
ECFP4 fingerprints 0.970 0.000 0.970 0.000 0.970 0.000 0.970 0.000 0.990 0.000 0.940 0.000 Download
ECFP6 fingerprints 0.940 0.000 0.980 0.000 0.960 0.000 0.960 0.000 0.990 0.000 0.930 0.000 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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