Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes. Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). Plays a role in synaptic vesicle trafficking. Phosphorylates PRDX3. Has GTPase activity. May play a role in the phosphorylation of proteins central to Parkinson disease.
| Uniprot primary ID | Q5S007 |
| PDB ID | 3D6T 2ZEJ |
| DrugBank ID | |
| BioGrid ID | 125700 |
| GuidetoPHARMACOLOGY ID | 2059 |
| PharmGKB ID | PA134968052 |
| KEGG ID | hsa:120892 |
| DIP ID | DIP-29684N |
| STRING ID | 9606.ENSP00000298910 |
| IntAct ID | Q5S007 |
| DMDM | 294862450 |
| BRENDA | |
| Reactome | |
| SignaLink | Q5S007 |
| BioCyc | |
| Entrez Gene (Gene ID) | 120892 |
| BindingDB | Q5S007 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.767 | 0.007 | 0.989 | 0.000 | 0.878 | 0.004 | 0.863 | 0.007 | 0.970 | 0.000 | 0.776 | 0.008 | Download |
| Estate fingerprints | 0.819 | 0.003 | 0.741 | 0.010 | 0.780 | 0.005 | 0.788 | 0.004 | 0.882 | 0.004 | 0.563 | 0.009 | Download |
| MACCS fingerprints | 0.893 | 0.007 | 0.821 | 0.005 | 0.857 | 0.005 | 0.861 | 0.003 | 0.932 | 0.004 | 0.714 | 0.008 | Download |
| Daylight fingerprints | 0.781 | 0.007 | 0.939 | 0.006 | 0.860 | 0.005 | 0.848 | 0.004 | 0.920 | 0.000 | 0.732 | 0.008 | Download |
| ECFP2 fingerprints | 0.924 | 0.005 | 0.936 | 0.006 | 0.930 | 0.005 | 0.930 | 0.005 | 0.971 | 0.003 | 0.863 | 0.007 | Download |
| ECFP4 fingerprints | 0.910 | 0.000 | 0.974 | 0.005 | 0.942 | 0.004 | 0.940 | 0.000 | 0.970 | 0.000 | 0.889 | 0.003 | Download |
| ECFP6 fingerprints | 0.898 | 0.004 | 0.984 | 0.000 | 0.941 | 0.003 | 0.940 | 0.000 | 0.970 | 0.000 | 0.889 | 0.003 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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