Target name

Q5S007: Leucine-rich repeat serine/threonine-protein kinase 2


  Protein function

Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes. Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). Plays a role in synaptic vesicle trafficking. Phosphorylates PRDX3. Has GTPase activity. May play a role in the phosphorylation of proteins central to Parkinson disease.

  Database links

Uniprot primary ID Q5S007
PDB ID 3D6T 2ZEJ
DrugBank ID
BioGrid ID 125700
GuidetoPHARMACOLOGY ID 2059
PharmGKB ID PA134968052
KEGG ID hsa:120892
DIP ID DIP-29684N
STRING ID 9606.ENSP00000298910
IntAct ID Q5S007
DMDM 294862450
BRENDA
Reactome
SignaLink Q5S007
BioCyc
Entrez Gene (Gene ID) 120892
BindingDB Q5S007

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.767 0.007 0.989 0.000 0.878 0.004 0.863 0.007 0.970 0.000 0.776 0.008 Download
Estate fingerprints 0.819 0.003 0.741 0.010 0.780 0.005 0.788 0.004 0.882 0.004 0.563 0.009 Download
MACCS fingerprints 0.893 0.007 0.821 0.005 0.857 0.005 0.861 0.003 0.932 0.004 0.714 0.008 Download
Daylight fingerprints 0.781 0.007 0.939 0.006 0.860 0.005 0.848 0.004 0.920 0.000 0.732 0.008 Download
ECFP2 fingerprints 0.924 0.005 0.936 0.006 0.930 0.005 0.930 0.005 0.971 0.003 0.863 0.007 Download
ECFP4 fingerprints 0.910 0.000 0.974 0.005 0.942 0.004 0.940 0.000 0.970 0.000 0.889 0.003 Download
ECFP6 fingerprints 0.898 0.004 0.984 0.000 0.941 0.003 0.940 0.000 0.970 0.000 0.889 0.003 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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