Target name

Q60492: Sigma non-opioid intracellular receptor 1


  Protein function

Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration (By similarity).

  Database links

Uniprot primary ID Q60492
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID
PharmGKB ID
KEGG ID
DIP ID
STRING ID 10141.ENSCPOP00000019032
IntAct ID
DMDM
BRENDA
Reactome
SignaLink
BioCyc
Entrez Gene (Gene ID) 100135589
BindingDB Q60492

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.862 0.004 0.878 0.003 0.870 0.000 0.870 0.000 0.940 0.000 0.740 0.005 Download
Estate fingerprints 0.889 0.003 0.831 0.000 0.860 0.000 0.861 0.003 0.930 0.000 0.716 0.007 Download
MACCS fingerprints 0.920 0.005 0.822 0.003 0.871 0.003 0.879 0.003 0.934 0.005 0.748 0.004 Download
Daylight fingerprints 0.799 0.003 0.801 0.005 0.800 0.000 0.800 0.000 0.860 0.000 0.603 0.005 Download
ECFP2 fingerprints 0.940 0.000 0.914 0.005 0.927 0.005 0.929 0.003 0.980 0.000 0.851 0.003 Download
ECFP4 fingerprints 0.930 0.000 0.944 0.004 0.937 0.005 0.937 0.005 0.990 0.000 0.871 0.003 Download
ECFP6 fingerprints 0.918 0.004 0.962 0.000 0.940 0.000 0.938 0.004 0.988 0.004 0.877 0.005 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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