Target name

Q62053: Prostaglandin E2 receptor EP2 subtype


  Protein function

Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle.

  Database links

Uniprot primary ID Q62053
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID 341
PharmGKB ID
KEGG ID mmu:19217
DIP ID
STRING ID 10090.ENSMUSP00000038483
IntAct ID
DMDM
BRENDA
Reactome R-MMU-418555 R-MMU-391908
SignaLink
BioCyc
Entrez Gene (Gene ID) 19217
BindingDB Q62053

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.906 0.013 0.968 0.005 0.937 0.008 0.935 0.007 0.990 0.000 0.877 0.014 Download
Estate fingerprints 0.950 0.008 0.934 0.005 0.942 0.006 0.942 0.006 0.980 0.000 0.882 0.011 Download
MACCS fingerprints 0.965 0.007 0.947 0.004 0.956 0.005 0.956 0.005 0.990 0.000 0.909 0.006 Download
Daylight fingerprints 0.884 0.012 0.844 0.000 0.864 0.005 0.866 0.007 0.908 0.004 0.725 0.012 Download
ECFP2 fingerprints 0.954 0.008 0.980 0.005 0.967 0.005 0.967 0.005 1.000 0.000 0.939 0.007 Download
ECFP4 fingerprints 0.976 0.007 0.984 0.005 0.980 0.005 0.980 0.005 1.000 0.000 0.960 0.005 Download
ECFP6 fingerprints 0.960 0.000 0.994 0.003 0.977 0.005 0.977 0.005 1.000 0.000 0.957 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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