Target name

Q62758: 5-hydroxytryptamine receptor 4


  Protein function

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.

  Database links

Uniprot primary ID Q62758
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID 9
PharmGKB ID
KEGG ID rno:25324
DIP ID
STRING ID 10116.ENSRNOP00000025892
IntAct ID
DMDM
BRENDA
Reactome
SignaLink
BioCyc
Entrez Gene (Gene ID) 25324
BindingDB Q62758

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.920 0.007 0.870 0.003 0.895 0.005 0.898 0.004 0.959 0.003 0.793 0.008 Download
Estate fingerprints 0.901 0.007 0.835 0.008 0.868 0.008 0.873 0.005 0.930 0.000 0.737 0.012 Download
MACCS fingerprints 0.881 0.007 0.847 0.004 0.864 0.005 0.869 0.003 0.940 0.000 0.733 0.007 Download
Daylight fingerprints 0.892 0.006 0.852 0.005 0.872 0.006 0.877 0.007 0.900 0.000 0.744 0.011 Download
ECFP2 fingerprints 0.935 0.005 0.943 0.004 0.939 0.003 0.939 0.003 0.973 0.005 0.874 0.008 Download
ECFP4 fingerprints 0.945 0.007 0.965 0.004 0.955 0.005 0.955 0.005 0.990 0.000 0.911 0.006 Download
ECFP6 fingerprints 0.928 0.004 0.972 0.005 0.950 0.000 0.950 0.000 0.990 0.000 0.903 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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