Target name

Q63470: Dual specificity tyrosine-phosphorylation-regulated kinase 1A


  Protein function

May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates such as CRY2, FOXO1, SRSF6 and SIRT1. Modulates alternative splicing by phosphorylating the splice factor SRSF6. Exhibits a sugstrate preference for proline at position P+1 and arginine at position P-3.

  Database links

Uniprot primary ID Q63470
PDB ID
DrugBank ID
BioGrid ID 247295
GuidetoPHARMACOLOGY ID 2009
PharmGKB ID
KEGG ID rno:25255
DIP ID
STRING ID 10116.ENSRNOP00000042446
IntAct ID Q63470
DMDM
BRENDA 2.7.12.1
Reactome R-RNO-1538133
SignaLink
BioCyc
Entrez Gene (Gene ID) 25255
BindingDB Q63470

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.990 0.000 0.964 0.007 0.977 0.005 0.977 0.005 0.992 0.004 0.947 0.007 Download
Estate fingerprints 0.813 0.008 0.863 0.005 0.838 0.006 0.834 0.007 0.940 0.000 0.675 0.010 Download
MACCS fingerprints 0.935 0.007 0.957 0.003 0.946 0.005 0.946 0.005 0.989 0.003 0.889 0.007 Download
Daylight fingerprints 0.903 0.012 0.977 0.000 0.940 0.007 0.938 0.009 0.982 0.004 0.886 0.013 Download
ECFP2 fingerprints 0.990 0.000 0.908 0.008 0.949 0.006 0.951 0.003 1.000 0.000 0.899 0.006 Download
ECFP4 fingerprints 0.990 0.000 0.942 0.007 0.966 0.005 0.969 0.003 1.000 0.000 0.934 0.008 Download
ECFP6 fingerprints 0.990 0.000 0.990 0.005 0.990 0.000 0.990 0.000 1.000 0.000 0.980 0.007 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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