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E-mail: biomed@csu.edu.cn
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Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells.
| Uniprot primary ID | Q64663 |
| PDB ID | |
| DrugBank ID | |
| BioGrid ID | 248286 |
| GuidetoPHARMACOLOGY ID | 484 |
| PharmGKB ID | |
| KEGG ID | rno:29665 |
| DIP ID | |
| STRING ID | 10116.ENSRNOP00000001746 |
| IntAct ID | Q64663 |
| DMDM | |
| BRENDA | |
| Reactome | R-RNO-844456 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 29665 |
| BindingDB | Q64663 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.917 | 0.007 | 0.951 | 0.005 | 0.934 | 0.005 | 0.934 | 0.005 | 0.980 | 0.000 | 0.869 | 0.007 | Download |
| Estate fingerprints | 0.944 | 0.005 | 0.892 | 0.007 | 0.918 | 0.004 | 0.919 | 0.003 | 0.970 | 0.000 | 0.836 | 0.008 | Download |
| MACCS fingerprints | 0.940 | 0.000 | 0.834 | 0.009 | 0.887 | 0.007 | 0.894 | 0.005 | 0.961 | 0.003 | 0.781 | 0.011 | Download |
| Daylight fingerprints | 0.798 | 0.006 | 0.966 | 0.005 | 0.882 | 0.004 | 0.871 | 0.006 | 0.950 | 0.000 | 0.771 | 0.011 | Download |
| ECFP2 fingerprints | 0.979 | 0.003 | 0.961 | 0.005 | 0.970 | 0.000 | 0.970 | 0.000 | 0.990 | 0.000 | 0.941 | 0.003 | Download |
| ECFP4 fingerprints | 0.970 | 0.000 | 0.990 | 0.005 | 0.980 | 0.000 | 0.980 | 0.000 | 0.990 | 0.000 | 0.960 | 0.000 | Download |
| ECFP6 fingerprints | 0.960 | 0.000 | 1.000 | 0.000 | 0.980 | 0.000 | 0.980 | 0.000 | 0.990 | 0.000 | 0.960 | 0.000 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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