Target name

Q64663: P2X purinoceptor 7


  Protein function

Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells.

  Database links

Uniprot primary ID Q64663
PDB ID
DrugBank ID
BioGrid ID 248286
GuidetoPHARMACOLOGY ID 484
PharmGKB ID
KEGG ID rno:29665
DIP ID
STRING ID 10116.ENSRNOP00000001746
IntAct ID Q64663
DMDM
BRENDA
Reactome R-RNO-844456
SignaLink
BioCyc
Entrez Gene (Gene ID) 29665
BindingDB Q64663

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.917 0.007 0.951 0.005 0.934 0.005 0.934 0.005 0.980 0.000 0.869 0.007 Download
Estate fingerprints 0.944 0.005 0.892 0.007 0.918 0.004 0.919 0.003 0.970 0.000 0.836 0.008 Download
MACCS fingerprints 0.940 0.000 0.834 0.009 0.887 0.007 0.894 0.005 0.961 0.003 0.781 0.011 Download
Daylight fingerprints 0.798 0.006 0.966 0.005 0.882 0.004 0.871 0.006 0.950 0.000 0.771 0.011 Download
ECFP2 fingerprints 0.979 0.003 0.961 0.005 0.970 0.000 0.970 0.000 0.990 0.000 0.941 0.003 Download
ECFP4 fingerprints 0.970 0.000 0.990 0.005 0.980 0.000 0.980 0.000 0.990 0.000 0.960 0.000 Download
ECFP6 fingerprints 0.960 0.000 1.000 0.000 0.980 0.000 0.980 0.000 0.990 0.000 0.960 0.000 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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