Target name

Q6B856: Tubulin beta-2B chain


  Protein function

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).

  Database links

Uniprot primary ID Q6B856
PDB ID 3E22 1TVK 3J1T 3J1U 3IZ0 2WBE 4ATX 4TV8 4TV9 4ATU 4I55 4CK6 4WBN 4O2A 4O2B 4O4J 4I50 4O4H 4IIJ 4O4L 4I4T 1SA1 3DCO 4YJ3 4YJ2 4TUY 1Z2B 4AQV 4AQW 4UXO 1SA0 4UXY 4UXT 4UXP 4UXS 4UXR 4IHJ 3J2U 4CK7 4UY0 4CK5 3DU7 2P4N 2XRP 4O4I
DrugBank ID
BioGrid ID 158875
GuidetoPHARMACOLOGY ID
PharmGKB ID
KEGG ID bta:281555
DIP ID DIP-47524N
STRING ID 9913.ENSBTAP00000005346
IntAct ID Q6B856
DMDM
BRENDA
Reactome R-BTA-389957 R-BTA-389960 R-BTA-190840 R-BTA-5663220 R-BTA-2500257 R-BTA-437239 R-BTA-5626467 R-BTA-380320 R-BTA-983189 R-BTA-5610787 R-BTA-5632684 R-BTA-190861 R-BTA-68877 R-BTA-5617833 R-BTA-5620924 R-BTA-1445148 R-BTA-2132295 R-BTA-2467813
SignaLink
BioCyc
Entrez Gene (Gene ID) 281555
BindingDB Q6B856

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.970 0.000 0.930 0.005 0.950 0.000 0.950 0.000 0.980 0.000 0.902 0.008 Download
Estate fingerprints 0.873 0.011 0.801 0.014 0.837 0.009 0.842 0.009 0.921 0.003 0.677 0.019 Download
MACCS fingerprints 0.964 0.008 0.874 0.007 0.919 0.006 0.922 0.004 0.950 0.000 0.841 0.009 Download
Daylight fingerprints 0.894 0.010 0.912 0.008 0.903 0.007 0.900 0.009 0.951 0.007 0.802 0.012 Download
ECFP2 fingerprints 0.988 0.006 0.908 0.006 0.948 0.004 0.949 0.003 0.990 0.000 0.900 0.009 Download
ECFP4 fingerprints 0.990 0.000 0.948 0.007 0.969 0.003 0.969 0.003 1.000 0.000 0.943 0.008 Download
ECFP6 fingerprints 0.997 0.005 0.963 0.000 0.980 0.000 0.980 0.000 1.000 0.000 0.967 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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