Target name

Q7TMR0: Lysosomal Pro-X carboxypeptidase


  Protein function

Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH (By similarity).

  Database links

Uniprot primary ID Q7TMR0
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID
PharmGKB ID
KEGG ID mmu:72461
DIP ID
STRING ID 10090.ENSMUSP00000075429
IntAct ID Q7TMR0
DMDM
BRENDA 3.4.16.2
Reactome R-MMU-140837
SignaLink
BioCyc
Entrez Gene (Gene ID) 72461
BindingDB Q7TMR0

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.926 0.008 0.978 0.000 0.952 0.004 0.951 0.006 0.991 0.003 0.908 0.008 Download
Estate fingerprints 0.933 0.007 0.917 0.009 0.925 0.007 0.925 0.007 0.979 0.003 0.848 0.013 Download
MACCS fingerprints 0.834 0.005 0.866 0.005 0.850 0.000 0.848 0.004 0.950 0.000 0.696 0.007 Download
Daylight fingerprints 0.839 0.009 0.957 0.012 0.898 0.009 0.892 0.009 0.919 0.003 0.803 0.018 Download
ECFP2 fingerprints 0.982 0.006 0.976 0.003 0.979 0.003 0.979 0.003 1.000 0.000 0.959 0.011 Download
ECFP4 fingerprints 0.998 0.004 1.000 0.000 1.000 0.000 1.000 0.000 1.000 0.000 0.998 0.004 Download
ECFP6 fingerprints 0.993 0.007 1.000 0.000 0.999 0.003 0.999 0.003 1.000 0.000 0.993 0.007 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
 E-mail: biomed@csu.edu.cn