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E-mail: biomed@csu.edu.cn
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Proto-oncogene with serine/threonine kinase activity that can prevent apoptosis, promote cell survival and protein translation. May contribute to tumorigenesis through: the delivery of survival signaling through phosphorylation of BAD which induces release of the anti-apoptotic protein Bcl-X(L), the regulation of cell cycle progression, protein synthesis and by regulation of MYC transcriptional activity. Additionally to this role on tumorigenesis, can also negatively regulate insulin secretion by inhibiting the activation of MAPK1/3 (ERK1/2), through SOCS6. Involved also in the control of energy metabolism and regulation of AMPK activity in modulating MYC and PPARGC1A protein levels and cell growth.
| Uniprot primary ID | Q86V86 |
| PDB ID | |
| DrugBank ID | |
| BioGrid ID | 136104 |
| GuidetoPHARMACOLOGY ID | 2160 |
| PharmGKB ID | PA134980758 |
| KEGG ID | hsa:415116 |
| DIP ID | |
| STRING ID | 9606.ENSP00000353824 |
| IntAct ID | Q86V86 |
| DMDM | 215274221 |
| BRENDA | |
| Reactome | |
| SignaLink | Q86V86 |
| BioCyc | |
| Entrez Gene (Gene ID) | 415116 |
| BindingDB | Q86V86 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.713 | 0.008 | 0.949 | 0.005 | 0.831 | 0.003 | 0.810 | 0.005 | 0.927 | 0.005 | 0.682 | 0.006 | Download |
| Estate fingerprints | 0.789 | 0.006 | 0.823 | 0.007 | 0.806 | 0.007 | 0.803 | 0.007 | 0.862 | 0.004 | 0.611 | 0.012 | Download |
| MACCS fingerprints | 0.801 | 0.010 | 0.827 | 0.005 | 0.814 | 0.007 | 0.813 | 0.007 | 0.907 | 0.005 | 0.625 | 0.011 | Download |
| Daylight fingerprints | 0.673 | 0.008 | 0.881 | 0.004 | 0.777 | 0.005 | 0.752 | 0.004 | 0.870 | 0.000 | 0.568 | 0.008 | Download |
| ECFP2 fingerprints | 0.912 | 0.006 | 0.952 | 0.005 | 0.932 | 0.004 | 0.932 | 0.004 | 0.970 | 0.000 | 0.867 | 0.007 | Download |
| ECFP4 fingerprints | 0.898 | 0.004 | 0.986 | 0.000 | 0.942 | 0.004 | 0.941 | 0.003 | 0.980 | 0.000 | 0.891 | 0.003 | Download |
| ECFP6 fingerprints | 0.857 | 0.005 | 0.997 | 0.000 | 0.927 | 0.005 | 0.920 | 0.000 | 0.971 | 0.003 | 0.860 | 0.005 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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