Target name

Q86V86: Serine/threonine-protein kinase pim-3


  Protein function

Proto-oncogene with serine/threonine kinase activity that can prevent apoptosis, promote cell survival and protein translation. May contribute to tumorigenesis through: the delivery of survival signaling through phosphorylation of BAD which induces release of the anti-apoptotic protein Bcl-X(L), the regulation of cell cycle progression, protein synthesis and by regulation of MYC transcriptional activity. Additionally to this role on tumorigenesis, can also negatively regulate insulin secretion by inhibiting the activation of MAPK1/3 (ERK1/2), through SOCS6. Involved also in the control of energy metabolism and regulation of AMPK activity in modulating MYC and PPARGC1A protein levels and cell growth.

  Database links

Uniprot primary ID Q86V86
PDB ID
DrugBank ID
BioGrid ID 136104
GuidetoPHARMACOLOGY ID 2160
PharmGKB ID PA134980758
KEGG ID hsa:415116
DIP ID
STRING ID 9606.ENSP00000353824
IntAct ID Q86V86
DMDM 215274221
BRENDA
Reactome
SignaLink Q86V86
BioCyc
Entrez Gene (Gene ID) 415116
BindingDB Q86V86

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.713 0.008 0.949 0.005 0.831 0.003 0.810 0.005 0.927 0.005 0.682 0.006 Download
Estate fingerprints 0.789 0.006 0.823 0.007 0.806 0.007 0.803 0.007 0.862 0.004 0.611 0.012 Download
MACCS fingerprints 0.801 0.010 0.827 0.005 0.814 0.007 0.813 0.007 0.907 0.005 0.625 0.011 Download
Daylight fingerprints 0.673 0.008 0.881 0.004 0.777 0.005 0.752 0.004 0.870 0.000 0.568 0.008 Download
ECFP2 fingerprints 0.912 0.006 0.952 0.005 0.932 0.004 0.932 0.004 0.970 0.000 0.867 0.007 Download
ECFP4 fingerprints 0.898 0.004 0.986 0.000 0.942 0.004 0.941 0.003 0.980 0.000 0.891 0.003 Download
ECFP6 fingerprints 0.857 0.005 0.997 0.000 0.927 0.005 0.920 0.000 0.971 0.003 0.860 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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