Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
| Uniprot primary ID | Q8T6T2 |
| PDB ID | 4RV8 4IXH 4QJ1 3FFS |
| DrugBank ID | |
| BioGrid ID | |
| GuidetoPHARMACOLOGY ID | |
| PharmGKB ID | |
| KEGG ID | |
| DIP ID | |
| STRING ID | 353152.XP_625342.1 |
| IntAct ID | |
| DMDM | |
| BRENDA | 1.1.1.205 |
| Reactome | |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | |
| BindingDB | Q8T6T2 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.944 | 0.010 | 0.968 | 0.005 | 0.956 | 0.005 | 0.956 | 0.005 | 0.990 | 0.000 | 0.912 | 0.012 | Download |
| Estate fingerprints | 0.937 | 0.013 | 0.831 | 0.005 | 0.884 | 0.007 | 0.893 | 0.008 | 0.950 | 0.000 | 0.775 | 0.016 | Download |
| MACCS fingerprints | 0.957 | 0.005 | 0.889 | 0.005 | 0.923 | 0.005 | 0.928 | 0.004 | 0.970 | 0.000 | 0.850 | 0.007 | Download |
| Daylight fingerprints | 0.904 | 0.016 | 0.994 | 0.003 | 0.949 | 0.010 | 0.947 | 0.009 | 0.991 | 0.003 | 0.901 | 0.016 | Download |
| ECFP2 fingerprints | 0.975 | 0.005 | 0.945 | 0.005 | 0.960 | 0.000 | 0.960 | 0.000 | 0.990 | 0.000 | 0.922 | 0.006 | Download |
| ECFP4 fingerprints | 0.975 | 0.005 | 0.961 | 0.005 | 0.968 | 0.004 | 0.968 | 0.004 | 0.999 | 0.003 | 0.933 | 0.005 | Download |
| ECFP6 fingerprints | 0.968 | 0.004 | 0.992 | 0.000 | 0.980 | 0.000 | 0.980 | 0.000 | 0.999 | 0.003 | 0.958 | 0.004 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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