Target name

Q8T6T2: Inosine-5'-monophosphate dehydrogenase


  Protein function

Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.

  Database links

Uniprot primary ID Q8T6T2
PDB ID 4RV8 4IXH 4QJ1 3FFS
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID
PharmGKB ID
KEGG ID
DIP ID
STRING ID 353152.XP_625342.1
IntAct ID
DMDM
BRENDA 1.1.1.205
Reactome
SignaLink
BioCyc
Entrez Gene (Gene ID)
BindingDB Q8T6T2

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.944 0.010 0.968 0.005 0.956 0.005 0.956 0.005 0.990 0.000 0.912 0.012 Download
Estate fingerprints 0.937 0.013 0.831 0.005 0.884 0.007 0.893 0.008 0.950 0.000 0.775 0.016 Download
MACCS fingerprints 0.957 0.005 0.889 0.005 0.923 0.005 0.928 0.004 0.970 0.000 0.850 0.007 Download
Daylight fingerprints 0.904 0.016 0.994 0.003 0.949 0.010 0.947 0.009 0.991 0.003 0.901 0.016 Download
ECFP2 fingerprints 0.975 0.005 0.945 0.005 0.960 0.000 0.960 0.000 0.990 0.000 0.922 0.006 Download
ECFP4 fingerprints 0.975 0.005 0.961 0.005 0.968 0.004 0.968 0.004 0.999 0.003 0.933 0.005 Download
ECFP6 fingerprints 0.968 0.004 0.992 0.000 0.980 0.000 0.980 0.000 0.999 0.003 0.958 0.004 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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