Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.
| Uniprot primary ID | Q8TDS4 |
| PDB ID | |
| DrugBank ID | DB00627 |
| BioGrid ID | |
| GuidetoPHARMACOLOGY ID | 312 |
| PharmGKB ID | PA165961843 |
| KEGG ID | hsa:338442 |
| DIP ID | |
| STRING ID | 9606.ENSP00000375066 |
| IntAct ID | |
| DMDM | 74762622 |
| BRENDA | |
| Reactome | R-HSA-418594 R-HSA-373076 R-HSA-3296197 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 338442 |
| BindingDB | Q8TDS4 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.863 | 0.005 | 0.977 | 0.004 | 0.920 | 0.000 | 0.915 | 0.005 | 0.980 | 0.000 | 0.846 | 0.005 | Download |
| Estate fingerprints | 0.857 | 0.007 | 0.859 | 0.004 | 0.858 | 0.004 | 0.858 | 0.004 | 0.942 | 0.004 | 0.715 | 0.005 | Download |
| MACCS fingerprints | 0.920 | 0.000 | 0.880 | 0.005 | 0.900 | 0.000 | 0.900 | 0.000 | 0.970 | 0.000 | 0.799 | 0.006 | Download |
| Daylight fingerprints | 0.833 | 0.007 | 0.839 | 0.003 | 0.836 | 0.005 | 0.836 | 0.005 | 0.902 | 0.004 | 0.672 | 0.008 | Download |
| ECFP2 fingerprints | 0.965 | 0.005 | 0.975 | 0.005 | 0.970 | 0.000 | 0.970 | 0.000 | 1.000 | 0.000 | 0.932 | 0.004 | Download |
| ECFP4 fingerprints | 0.990 | 0.000 | 0.990 | 0.000 | 0.990 | 0.000 | 0.990 | 0.000 | 1.000 | 0.000 | 0.977 | 0.005 | Download |
| ECFP6 fingerprints | 0.990 | 0.000 | 0.990 | 0.005 | 0.990 | 0.000 | 0.990 | 0.000 | 1.000 | 0.000 | 0.979 | 0.003 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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