Target name

Q8TDS4: Hydroxycarboxylic acid receptor 2


  Protein function

Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.

  Database links

Uniprot primary ID Q8TDS4
PDB ID
DrugBank ID DB00627
BioGrid ID
GuidetoPHARMACOLOGY ID 312
PharmGKB ID PA165961843
KEGG ID hsa:338442
DIP ID
STRING ID 9606.ENSP00000375066
IntAct ID
DMDM 74762622
BRENDA
Reactome R-HSA-418594 R-HSA-373076 R-HSA-3296197
SignaLink
BioCyc
Entrez Gene (Gene ID) 338442
BindingDB Q8TDS4

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.863 0.005 0.977 0.004 0.920 0.000 0.915 0.005 0.980 0.000 0.846 0.005 Download
Estate fingerprints 0.857 0.007 0.859 0.004 0.858 0.004 0.858 0.004 0.942 0.004 0.715 0.005 Download
MACCS fingerprints 0.920 0.000 0.880 0.005 0.900 0.000 0.900 0.000 0.970 0.000 0.799 0.006 Download
Daylight fingerprints 0.833 0.007 0.839 0.003 0.836 0.005 0.836 0.005 0.902 0.004 0.672 0.008 Download
ECFP2 fingerprints 0.965 0.005 0.975 0.005 0.970 0.000 0.970 0.000 1.000 0.000 0.932 0.004 Download
ECFP4 fingerprints 0.990 0.000 0.990 0.000 0.990 0.000 0.990 0.000 1.000 0.000 0.977 0.005 Download
ECFP6 fingerprints 0.990 0.000 0.990 0.005 0.990 0.000 0.990 0.000 1.000 0.000 0.979 0.003 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
 E-mail: biomed@csu.edu.cn