Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids.
| Uniprot primary ID | Q8TDU6 |
| PDB ID | |
| DrugBank ID | |
| BioGrid ID | |
| GuidetoPHARMACOLOGY ID | 37 |
| PharmGKB ID | PA134903170 |
| KEGG ID | hsa:151306 |
| DIP ID | |
| STRING ID | 9606.ENSP00000428824 |
| IntAct ID | Q8TDU6 |
| DMDM | 74762624 |
| BRENDA | |
| Reactome | R-HSA-373076 R-HSA-418555 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 151306 |
| BindingDB | Q8TDU6 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.760 | 0.000 | 0.980 | 0.000 | 0.870 | 0.000 | 0.854 | 0.005 | 0.990 | 0.000 | 0.760 | 0.000 | Download |
| Estate fingerprints | 0.778 | 0.008 | 0.856 | 0.006 | 0.817 | 0.005 | 0.808 | 0.006 | 0.894 | 0.005 | 0.634 | 0.010 | Download |
| MACCS fingerprints | 0.742 | 0.009 | 0.848 | 0.004 | 0.795 | 0.005 | 0.785 | 0.007 | 0.877 | 0.005 | 0.595 | 0.011 | Download |
| Daylight fingerprints | 0.676 | 0.005 | 1.000 | 0.000 | 0.838 | 0.004 | 0.808 | 0.004 | 0.896 | 0.005 | 0.716 | 0.005 | Download |
| ECFP2 fingerprints | 0.957 | 0.019 | 0.973 | 0.003 | 0.965 | 0.011 | 0.965 | 0.011 | 0.990 | 0.000 | 0.927 | 0.021 | Download |
| ECFP4 fingerprints | 0.988 | 0.004 | 0.992 | 0.003 | 0.990 | 0.000 | 0.990 | 0.000 | 1.000 | 0.000 | 0.977 | 0.005 | Download |
| ECFP6 fingerprints | 0.967 | 0.005 | 1.000 | 0.000 | 0.984 | 0.005 | 0.984 | 0.005 | 1.000 | 0.000 | 0.967 | 0.005 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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