Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway.
| Uniprot primary ID | Q8TDV5 |
| PDB ID | |
| DrugBank ID | |
| BioGrid ID | 126586 |
| GuidetoPHARMACOLOGY ID | 126 |
| PharmGKB ID | PA134928131 |
| KEGG ID | hsa:139760 |
| DIP ID | |
| STRING ID | 9606.ENSP00000276218 |
| IntAct ID | |
| DMDM | 62510696 |
| BRENDA | |
| Reactome | R-HSA-400511 R-HSA-381771 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 139760 |
| BindingDB | Q8TDV5 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.908 | 0.004 | 0.984 | 0.000 | 0.946 | 0.005 | 0.944 | 0.005 | 0.990 | 0.000 | 0.894 | 0.005 | Download |
| Estate fingerprints | 0.970 | 0.000 | 0.930 | 0.005 | 0.950 | 0.000 | 0.950 | 0.000 | 0.980 | 0.000 | 0.899 | 0.003 | Download |
| MACCS fingerprints | 0.895 | 0.005 | 0.925 | 0.000 | 0.910 | 0.000 | 0.909 | 0.003 | 0.970 | 0.000 | 0.814 | 0.005 | Download |
| Daylight fingerprints | 0.877 | 0.005 | 1.000 | 0.005 | 0.939 | 0.003 | 0.935 | 0.005 | 0.990 | 0.000 | 0.884 | 0.007 | Download |
| ECFP2 fingerprints | 0.984 | 0.005 | 0.990 | 0.003 | 0.987 | 0.005 | 0.987 | 0.005 | 1.000 | 0.000 | 0.973 | 0.005 | Download |
| ECFP4 fingerprints | 0.990 | 0.000 | 0.990 | 0.000 | 0.990 | 0.000 | 0.990 | 0.000 | 1.000 | 0.000 | 0.980 | 0.000 | Download |
| ECFP6 fingerprints | 0.990 | 0.000 | 0.990 | 0.000 | 0.990 | 0.000 | 0.990 | 0.000 | 1.000 | 0.000 | 0.984 | 0.005 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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