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Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A.
| Uniprot primary ID | Q8WW43 |
| PDB ID | |
| DrugBank ID | |
| BioGrid ID | 123659 |
| GuidetoPHARMACOLOGY ID | |
| PharmGKB ID | PA142672600 |
| KEGG ID | hsa:83464 |
| DIP ID | |
| STRING ID | 9606.ENSP00000261879 |
| IntAct ID | Q8WW43 |
| DMDM | 61252592 |
| BRENDA | |
| Reactome | R-HSA-193692 R-HSA-1980150 R-HSA-1980148 R-HSA-2644606 R-HSA-3928665 R-HSA-205043 R-HSA-2122948 R-HSA-2894862 R-HSA-1251985 R-HSA-2979096 |
| SignaLink | Q8WW43 |
| BioCyc | |
| Entrez Gene (Gene ID) | 83464 |
| BindingDB | Q8WW43 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.966 | 0.005 | 0.914 | 0.003 | 0.940 | 0.000 | 0.942 | 0.004 | 0.987 | 0.005 | 0.881 | 0.006 | Download |
| Estate fingerprints | 0.977 | 0.005 | 0.797 | 0.007 | 0.887 | 0.007 | 0.895 | 0.005 | 0.940 | 0.000 | 0.784 | 0.010 | Download |
| MACCS fingerprints | 0.709 | 0.007 | 0.845 | 0.005 | 0.777 | 0.005 | 0.760 | 0.007 | 0.909 | 0.003 | 0.561 | 0.009 | Download |
| Daylight fingerprints | 0.882 | 0.006 | 0.976 | 0.005 | 0.929 | 0.003 | 0.925 | 0.005 | 0.970 | 0.000 | 0.860 | 0.008 | Download |
| ECFP2 fingerprints | 0.998 | 0.004 | 0.958 | 0.007 | 0.978 | 0.004 | 0.978 | 0.004 | 1.000 | 0.000 | 0.954 | 0.008 | Download |
| ECFP4 fingerprints | 0.990 | 0.000 | 0.988 | 0.005 | 0.989 | 0.003 | 0.989 | 0.003 | 1.000 | 0.000 | 0.982 | 0.006 | Download |
| ECFP6 fingerprints | 0.988 | 0.004 | 0.992 | 0.000 | 0.990 | 0.000 | 0.990 | 0.000 | 1.000 | 0.000 | 0.979 | 0.003 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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