Target name

Q8WW43: Gamma-secretase subunit APH-1B


  Protein function

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A.

  Database links

Uniprot primary ID Q8WW43
PDB ID
DrugBank ID
BioGrid ID 123659
GuidetoPHARMACOLOGY ID
PharmGKB ID PA142672600
KEGG ID hsa:83464
DIP ID
STRING ID 9606.ENSP00000261879
IntAct ID Q8WW43
DMDM 61252592
BRENDA
Reactome R-HSA-193692 R-HSA-1980150 R-HSA-1980148 R-HSA-2644606 R-HSA-3928665 R-HSA-205043 R-HSA-2122948 R-HSA-2894862 R-HSA-1251985 R-HSA-2979096
SignaLink Q8WW43
BioCyc
Entrez Gene (Gene ID) 83464
BindingDB Q8WW43

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.966 0.005 0.914 0.003 0.940 0.000 0.942 0.004 0.987 0.005 0.881 0.006 Download
Estate fingerprints 0.977 0.005 0.797 0.007 0.887 0.007 0.895 0.005 0.940 0.000 0.784 0.010 Download
MACCS fingerprints 0.709 0.007 0.845 0.005 0.777 0.005 0.760 0.007 0.909 0.003 0.561 0.009 Download
Daylight fingerprints 0.882 0.006 0.976 0.005 0.929 0.003 0.925 0.005 0.970 0.000 0.860 0.008 Download
ECFP2 fingerprints 0.998 0.004 0.958 0.007 0.978 0.004 0.978 0.004 1.000 0.000 0.954 0.008 Download
ECFP4 fingerprints 0.990 0.000 0.988 0.005 0.989 0.003 0.989 0.003 1.000 0.000 0.982 0.006 Download
ECFP6 fingerprints 0.988 0.004 0.992 0.000 0.990 0.000 0.990 0.000 1.000 0.000 0.979 0.003 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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