Target name

Q923Y8: Trace amine-associated receptor 1


  Protein function

Receptor for trace amines, including beta-phenylethylamine (b-PEA), p-tyramine (p-TYR), octopamine and tryptamine, with highest affinity for b-PEA and p-TYR. Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonine. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. The signal transduced by this receptor is mediated by the G(s)-class of G-proteins which activate adenylate cyclase.

  Database links

Uniprot primary ID Q923Y8
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID 364
PharmGKB ID
KEGG ID mmu:111174
DIP ID
STRING ID 10090.ENSMUSP00000049527
IntAct ID
DMDM
BRENDA
Reactome R-MMU-375280 R-MMU-418555
SignaLink
BioCyc
Entrez Gene (Gene ID) 111174
BindingDB Q923Y8

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.990 0.000 0.952 0.000 0.971 0.003 0.971 0.003 1.000 0.000 0.944 0.005 Download
Estate fingerprints 0.851 0.006 0.887 0.005 0.869 0.003 0.868 0.004 0.960 0.000 0.738 0.008 Download
MACCS fingerprints 0.934 0.008 0.942 0.004 0.938 0.004 0.938 0.004 0.970 0.000 0.879 0.009 Download
Daylight fingerprints 0.834 0.005 0.844 0.000 0.839 0.003 0.839 0.003 0.900 0.000 0.674 0.005 Download
ECFP2 fingerprints 0.970 0.005 0.968 0.000 0.969 0.003 0.969 0.003 1.000 0.000 0.940 0.005 Download
ECFP4 fingerprints 1.000 0.000 0.980 0.003 0.990 0.000 0.990 0.000 1.000 0.000 0.978 0.004 Download
ECFP6 fingerprints 1.000 0.000 0.980 0.000 0.990 0.000 0.990 0.000 1.000 0.000 0.984 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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