Target name

Q92542: Nicastrin


  Protein function

Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex.

  Database links

Uniprot primary ID Q92542
PDB ID 4UIS 5A63 4UPC
DrugBank ID
BioGrid ID 116961
GuidetoPHARMACOLOGY ID
PharmGKB ID PA142671271
KEGG ID hsa:23385
DIP ID DIP-36336N
STRING ID 9606.ENSP00000294785
IntAct ID Q92542
DMDM 12231037
BRENDA
Reactome R-HSA-193692 R-HSA-1980150 R-HSA-1980148 R-HSA-1474228 R-HSA-2644606 R-HSA-3928665 R-HSA-205043 R-HSA-2122948 R-HSA-2894862 R-HSA-1251985 R-HSA-2979096
SignaLink Q92542
BioCyc
Entrez Gene (Gene ID) 23385
BindingDB Q92542

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.923 0.011 0.943 0.003 0.933 0.005 0.932 0.004 0.980 0.000 0.865 0.012 Download
Estate fingerprints 0.914 0.007 0.824 0.007 0.869 0.003 0.875 0.007 0.940 0.000 0.743 0.009 Download
MACCS fingerprints 0.740 0.000 0.820 0.005 0.780 0.000 0.770 0.000 0.920 0.000 0.556 0.005 Download
Daylight fingerprints 0.776 0.011 0.980 0.005 0.878 0.006 0.867 0.007 0.971 0.003 0.777 0.009 Download
ECFP2 fingerprints 0.998 0.004 0.962 0.003 0.980 0.000 0.980 0.000 1.000 0.000 0.956 0.005 Download
ECFP4 fingerprints 0.981 0.003 0.981 0.003 0.981 0.003 0.981 0.003 1.000 0.000 0.959 0.006 Download
ECFP6 fingerprints 0.978 0.004 0.998 0.000 0.988 0.004 0.988 0.004 1.000 0.000 0.975 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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