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Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex.
| Uniprot primary ID | Q92542 |
| PDB ID | 4UIS 5A63 4UPC |
| DrugBank ID | |
| BioGrid ID | 116961 |
| GuidetoPHARMACOLOGY ID | |
| PharmGKB ID | PA142671271 |
| KEGG ID | hsa:23385 |
| DIP ID | DIP-36336N |
| STRING ID | 9606.ENSP00000294785 |
| IntAct ID | Q92542 |
| DMDM | 12231037 |
| BRENDA | |
| Reactome | R-HSA-193692 R-HSA-1980150 R-HSA-1980148 R-HSA-1474228 R-HSA-2644606 R-HSA-3928665 R-HSA-205043 R-HSA-2122948 R-HSA-2894862 R-HSA-1251985 R-HSA-2979096 |
| SignaLink | Q92542 |
| BioCyc | |
| Entrez Gene (Gene ID) | 23385 |
| BindingDB | Q92542 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.923 | 0.011 | 0.943 | 0.003 | 0.933 | 0.005 | 0.932 | 0.004 | 0.980 | 0.000 | 0.865 | 0.012 | Download |
| Estate fingerprints | 0.914 | 0.007 | 0.824 | 0.007 | 0.869 | 0.003 | 0.875 | 0.007 | 0.940 | 0.000 | 0.743 | 0.009 | Download |
| MACCS fingerprints | 0.740 | 0.000 | 0.820 | 0.005 | 0.780 | 0.000 | 0.770 | 0.000 | 0.920 | 0.000 | 0.556 | 0.005 | Download |
| Daylight fingerprints | 0.776 | 0.011 | 0.980 | 0.005 | 0.878 | 0.006 | 0.867 | 0.007 | 0.971 | 0.003 | 0.777 | 0.009 | Download |
| ECFP2 fingerprints | 0.998 | 0.004 | 0.962 | 0.003 | 0.980 | 0.000 | 0.980 | 0.000 | 1.000 | 0.000 | 0.956 | 0.005 | Download |
| ECFP4 fingerprints | 0.981 | 0.003 | 0.981 | 0.003 | 0.981 | 0.003 | 0.981 | 0.003 | 1.000 | 0.000 | 0.959 | 0.006 | Download |
| ECFP6 fingerprints | 0.978 | 0.004 | 0.998 | 0.000 | 0.988 | 0.004 | 0.988 | 0.004 | 1.000 | 0.000 | 0.975 | 0.005 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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