Target name

Q92731: Estrogen receptor beta


  Protein function

Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (PubMed:20074560). Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.

  Database links

Uniprot primary ID Q92731
PDB ID 1U9E 1L2J 1ZAF 1X7B 4J24 4J26 1YY4 3OMO 2NV7 2JJ3 1X76 2YJD 2Z4B 3OMQ 3OMP 1X78 2GIU 2I0G 1X7J 2QTU 1YYE 3OLL 1QKM 1U3R 1U3S 2YLY 1U3Q 2FSZ 1NDE 3OLS
DrugBank ID DB00481 DB04574 DB01108 DB01196 DB04573 DB00783 DB00675
BioGrid ID 108404
GuidetoPHARMACOLOGY ID 621
PharmGKB ID PA27886
KEGG ID hsa:2100
DIP ID DIP-5966N
STRING ID 9606.ENSP00000343925
IntAct ID Q92731
DMDM 6166154
BRENDA
Reactome R-HSA-383280
SignaLink Q92731
BioCyc
Entrez Gene (Gene ID) 2100
BindingDB Q92731

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.800 0.000 0.840 0.004 0.820 0.000 0.820 0.000 0.890 0.000 0.644 0.005 Download
Estate fingerprints 0.810 0.000 0.846 0.000 0.828 0.004 0.822 0.004 0.890 0.000 0.654 0.005 Download
MACCS fingerprints 0.770 0.000 0.850 0.005 0.810 0.000 0.800 0.000 0.880 0.000 0.620 0.000 Download
Daylight fingerprints 0.721 0.003 0.759 0.000 0.740 0.000 0.740 0.000 0.790 0.000 0.481 0.003 Download
ECFP2 fingerprints 0.870 0.000 0.910 0.004 0.890 0.000 0.890 0.000 0.960 0.000 0.789 0.003 Download
ECFP4 fingerprints 0.873 0.005 0.967 0.000 0.920 0.000 0.911 0.003 0.960 0.000 0.840 0.000 Download
ECFP6 fingerprints 0.857 0.005 0.963 0.005 0.910 0.000 0.909 0.003 0.960 0.000 0.830 0.000 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
 E-mail: biomed@csu.edu.cn