Target name

Q96BI3: Gamma-secretase subunit APH-1A


  Protein function

Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex.

  Database links

Uniprot primary ID Q96BI3
PDB ID 5A63
DrugBank ID
BioGrid ID 119296
GuidetoPHARMACOLOGY ID
PharmGKB ID PA142672599
KEGG ID hsa:51107
DIP ID
STRING ID 9606.ENSP00000358105
IntAct ID Q96BI3
DMDM 37077707
BRENDA
Reactome R-HSA-193692 R-HSA-1980150 R-HSA-1980148 R-HSA-2644606 R-HSA-3928665 R-HSA-205043 R-HSA-2122948 R-HSA-2894862 R-HSA-1251985 R-HSA-2979096
SignaLink Q96BI3
BioCyc
Entrez Gene (Gene ID) 51107
BindingDB Q96BI3

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.860 0.008 0.924 0.003 0.892 0.006 0.891 0.006 0.970 0.000 0.791 0.011 Download
Estate fingerprints 0.887 0.009 0.909 0.008 0.898 0.008 0.898 0.008 0.969 0.003 0.800 0.013 Download
MACCS fingerprints 0.800 0.000 0.840 0.000 0.820 0.000 0.820 0.000 0.920 0.000 0.640 0.000 Download
Daylight fingerprints 0.778 0.012 0.974 0.000 0.876 0.005 0.865 0.007 0.954 0.005 0.771 0.010 Download
ECFP2 fingerprints 0.976 0.008 0.958 0.005 0.967 0.005 0.967 0.005 1.000 0.000 0.933 0.005 Download
ECFP4 fingerprints 0.968 0.004 0.986 0.007 0.977 0.005 0.977 0.005 1.000 0.000 0.951 0.007 Download
ECFP6 fingerprints 0.959 0.003 1.000 0.000 0.980 0.000 0.980 0.000 1.000 0.000 0.962 0.006 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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