Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.
| Uniprot primary ID | Q96RI1 |
| PDB ID | 4OIV 3L1B 3OKH 4QE6 3OKI 3OMK 1OSH 1OSK 4QE8 3HC5 3HC6 3OMM 3OOF 3RVF 3OOK 3DCT 3DCU 3BEJ 3RUT 3RUU 3P89 3P88 3FXV 4WVD 3OLF 3GD2 3FLI |
| DrugBank ID | DB06777 |
| BioGrid ID | 115296 |
| GuidetoPHARMACOLOGY ID | 603 |
| PharmGKB ID | PA31752 |
| KEGG ID | hsa:9971 |
| DIP ID | DIP-39370N |
| STRING ID | 9606.ENSP00000447149 |
| IntAct ID | Q96RI1 |
| DMDM | 46577705 |
| BRENDA | |
| Reactome | R-HSA-1989781 R-HSA-383280 R-HSA-193807 R-HSA-193368 R-HSA-211976 R-HSA-192105 R-HSA-159418 |
| SignaLink | Q96RI1 |
| BioCyc | |
| Entrez Gene (Gene ID) | 9971 |
| BindingDB | Q96RI1 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.759 | 0.006 | 0.999 | 0.000 | 0.879 | 0.003 | 0.867 | 0.005 | 0.990 | 0.000 | 0.786 | 0.007 | Download |
| Estate fingerprints | 0.825 | 0.005 | 0.815 | 0.000 | 0.820 | 0.000 | 0.820 | 0.000 | 0.918 | 0.004 | 0.640 | 0.000 | Download |
| MACCS fingerprints | 0.831 | 0.003 | 0.869 | 0.005 | 0.850 | 0.000 | 0.850 | 0.000 | 0.930 | 0.000 | 0.702 | 0.004 | Download |
| Daylight fingerprints | 0.801 | 0.006 | 0.969 | 0.005 | 0.885 | 0.005 | 0.873 | 0.007 | 0.870 | 0.000 | 0.777 | 0.008 | Download |
| ECFP2 fingerprints | 0.979 | 0.003 | 0.973 | 0.005 | 0.976 | 0.005 | 0.976 | 0.005 | 0.990 | 0.000 | 0.949 | 0.003 | Download |
| ECFP4 fingerprints | 0.980 | 0.000 | 0.996 | 0.004 | 0.988 | 0.004 | 0.988 | 0.004 | 0.990 | 0.000 | 0.975 | 0.005 | Download |
| ECFP6 fingerprints | 0.960 | 0.000 | 1.000 | 0.000 | 0.980 | 0.000 | 0.980 | 0.000 | 0.990 | 0.000 | 0.959 | 0.003 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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