Target name

Q96RI1: Bile acid receptor


  Protein function

Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.

  Database links

Uniprot primary ID Q96RI1
PDB ID 4OIV 3L1B 3OKH 4QE6 3OKI 3OMK 1OSH 1OSK 4QE8 3HC5 3HC6 3OMM 3OOF 3RVF 3OOK 3DCT 3DCU 3BEJ 3RUT 3RUU 3P89 3P88 3FXV 4WVD 3OLF 3GD2 3FLI
DrugBank ID DB06777
BioGrid ID 115296
GuidetoPHARMACOLOGY ID 603
PharmGKB ID PA31752
KEGG ID hsa:9971
DIP ID DIP-39370N
STRING ID 9606.ENSP00000447149
IntAct ID Q96RI1
DMDM 46577705
BRENDA
Reactome R-HSA-1989781 R-HSA-383280 R-HSA-193807 R-HSA-193368 R-HSA-211976 R-HSA-192105 R-HSA-159418
SignaLink Q96RI1
BioCyc
Entrez Gene (Gene ID) 9971
BindingDB Q96RI1

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.759 0.006 0.999 0.000 0.879 0.003 0.867 0.005 0.990 0.000 0.786 0.007 Download
Estate fingerprints 0.825 0.005 0.815 0.000 0.820 0.000 0.820 0.000 0.918 0.004 0.640 0.000 Download
MACCS fingerprints 0.831 0.003 0.869 0.005 0.850 0.000 0.850 0.000 0.930 0.000 0.702 0.004 Download
Daylight fingerprints 0.801 0.006 0.969 0.005 0.885 0.005 0.873 0.007 0.870 0.000 0.777 0.008 Download
ECFP2 fingerprints 0.979 0.003 0.973 0.005 0.976 0.005 0.976 0.005 0.990 0.000 0.949 0.003 Download
ECFP4 fingerprints 0.980 0.000 0.996 0.004 0.988 0.004 0.988 0.004 0.990 0.000 0.975 0.005 Download
ECFP6 fingerprints 0.960 0.000 1.000 0.000 0.980 0.000 0.980 0.000 0.990 0.000 0.959 0.003 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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