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Receptor for trace amines, including beta-phenylethylamine (b-PEA), p-tyramine (p-TYR), octopamine and tryptamine, with highest affinity for b-PEA and p-TYR. Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonine. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. The signal transduced by this receptor is mediated by the G(s)-class of G-proteins which activate adenylate cyclase.
| Uniprot primary ID | Q96RJ0 |
| PDB ID | |
| DrugBank ID | DB01576 DB01577 DB00182 DB06714 |
| BioGrid ID | 126416 |
| GuidetoPHARMACOLOGY ID | 364 |
| PharmGKB ID | PA134921784 |
| KEGG ID | hsa:134864 |
| DIP ID | |
| STRING ID | 9606.ENSP00000275216 |
| IntAct ID | |
| DMDM | 38258636 |
| BRENDA | |
| Reactome | R-HSA-418555 R-HSA-375280 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 134864 |
| BindingDB | Q96RJ0 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.742 | 0.006 | 0.750 | 0.008 | 0.746 | 0.005 | 0.745 | 0.005 | 0.850 | 0.000 | 0.490 | 0.007 | Download |
| Estate fingerprints | 0.738 | 0.004 | 0.714 | 0.008 | 0.726 | 0.005 | 0.729 | 0.003 | 0.798 | 0.004 | 0.452 | 0.011 | Download |
| MACCS fingerprints | 0.663 | 0.007 | 0.773 | 0.004 | 0.718 | 0.004 | 0.700 | 0.005 | 0.792 | 0.004 | 0.441 | 0.007 | Download |
| Daylight fingerprints | 0.619 | 0.006 | 0.777 | 0.005 | 0.698 | 0.004 | 0.671 | 0.003 | 0.750 | 0.000 | 0.399 | 0.006 | Download |
| ECFP2 fingerprints | 0.867 | 0.009 | 0.831 | 0.009 | 0.849 | 0.006 | 0.853 | 0.007 | 0.930 | 0.000 | 0.699 | 0.014 | Download |
| ECFP4 fingerprints | 0.896 | 0.005 | 0.864 | 0.006 | 0.880 | 0.007 | 0.882 | 0.004 | 0.954 | 0.005 | 0.760 | 0.007 | Download |
| ECFP6 fingerprints | 0.874 | 0.007 | 0.904 | 0.008 | 0.889 | 0.007 | 0.887 | 0.007 | 0.959 | 0.003 | 0.778 | 0.010 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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