Target name

Q96RJ0: Trace amine-associated receptor 1


  Protein function

Receptor for trace amines, including beta-phenylethylamine (b-PEA), p-tyramine (p-TYR), octopamine and tryptamine, with highest affinity for b-PEA and p-TYR. Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonine. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. The signal transduced by this receptor is mediated by the G(s)-class of G-proteins which activate adenylate cyclase.

  Database links

Uniprot primary ID Q96RJ0
PDB ID
DrugBank ID DB01576 DB01577 DB00182 DB06714
BioGrid ID 126416
GuidetoPHARMACOLOGY ID 364
PharmGKB ID PA134921784
KEGG ID hsa:134864
DIP ID
STRING ID 9606.ENSP00000275216
IntAct ID
DMDM 38258636
BRENDA
Reactome R-HSA-418555 R-HSA-375280
SignaLink
BioCyc
Entrez Gene (Gene ID) 134864
BindingDB Q96RJ0

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.742 0.006 0.750 0.008 0.746 0.005 0.745 0.005 0.850 0.000 0.490 0.007 Download
Estate fingerprints 0.738 0.004 0.714 0.008 0.726 0.005 0.729 0.003 0.798 0.004 0.452 0.011 Download
MACCS fingerprints 0.663 0.007 0.773 0.004 0.718 0.004 0.700 0.005 0.792 0.004 0.441 0.007 Download
Daylight fingerprints 0.619 0.006 0.777 0.005 0.698 0.004 0.671 0.003 0.750 0.000 0.399 0.006 Download
ECFP2 fingerprints 0.867 0.009 0.831 0.009 0.849 0.006 0.853 0.007 0.930 0.000 0.699 0.014 Download
ECFP4 fingerprints 0.896 0.005 0.864 0.006 0.880 0.007 0.882 0.004 0.954 0.005 0.760 0.007 Download
ECFP6 fingerprints 0.874 0.007 0.904 0.008 0.889 0.007 0.887 0.007 0.959 0.003 0.778 0.010 Download

  Download datasets

Positive dataset Negative dataset


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 E-mail: biomed@csu.edu.cn