Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells.
| Uniprot primary ID | Q99572 |
| PDB ID | |
| DrugBank ID | |
| BioGrid ID | 111066 |
| GuidetoPHARMACOLOGY ID | 484 |
| PharmGKB ID | PA32866 |
| KEGG ID | hsa:5027 |
| DIP ID | |
| STRING ID | 9606.ENSP00000442349 |
| IntAct ID | Q99572 |
| DMDM | 395398617 |
| BRENDA | |
| Reactome | R-HSA-844456 |
| SignaLink | Q99572 |
| BioCyc | |
| Entrez Gene (Gene ID) | 5027 |
| BindingDB | Q99572 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.899 | 0.007 | 0.909 | 0.003 | 0.904 | 0.005 | 0.904 | 0.005 | 0.961 | 0.003 | 0.805 | 0.007 | Download |
| Estate fingerprints | 0.876 | 0.005 | 0.844 | 0.007 | 0.860 | 0.005 | 0.863 | 0.005 | 0.920 | 0.000 | 0.720 | 0.008 | Download |
| MACCS fingerprints | 0.827 | 0.005 | 0.819 | 0.005 | 0.823 | 0.005 | 0.825 | 0.005 | 0.889 | 0.003 | 0.648 | 0.006 | Download |
| Daylight fingerprints | 0.828 | 0.004 | 0.794 | 0.003 | 0.811 | 0.003 | 0.815 | 0.005 | 0.860 | 0.000 | 0.622 | 0.004 | Download |
| ECFP2 fingerprints | 0.957 | 0.005 | 0.943 | 0.003 | 0.950 | 0.000 | 0.951 | 0.003 | 0.990 | 0.000 | 0.902 | 0.006 | Download |
| ECFP4 fingerprints | 0.977 | 0.005 | 0.971 | 0.005 | 0.974 | 0.005 | 0.974 | 0.005 | 1.000 | 0.000 | 0.949 | 0.006 | Download |
| ECFP6 fingerprints | 0.966 | 0.005 | 0.992 | 0.000 | 0.979 | 0.003 | 0.977 | 0.005 | 1.000 | 0.000 | 0.957 | 0.005 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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