TargetNet
  Target name

Q99572: P2X purinoceptor 7

  Protein function

Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells.

  Database links
Uniprot primary ID Q99572
PDB ID
DrugBank ID
BioGrid ID 111066
GuidetoPHARMACOLOGY ID 484
PharmGKB ID PA32866
KEGG ID hsa:5027
DIP ID
STRING ID 9606.ENSP00000442349
IntAct ID Q99572
DMDM 395398617
BRENDA
Reactome R-HSA-844456
SignaLink Q99572
BioCyc
Entrez Gene (Gene ID) 5027
BindingDB Q99572
  Model Performance Metrics
Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.899 0.007 0.909 0.003 0.904 0.005 0.904 0.005 0.961 0.003 0.805 0.007 Download
Estate fingerprints 0.876 0.005 0.844 0.007 0.860 0.005 0.863 0.005 0.920 0.000 0.720 0.008 Download
MACCS fingerprints 0.827 0.005 0.819 0.005 0.823 0.005 0.825 0.005 0.889 0.003 0.648 0.006 Download
Daylight fingerprints 0.828 0.004 0.794 0.003 0.811 0.003 0.815 0.005 0.860 0.000 0.622 0.004 Download
ECFP2 fingerprints 0.957 0.005 0.943 0.003 0.950 0.000 0.951 0.003 0.990 0.000 0.902 0.006 Download
ECFP4 fingerprints 0.977 0.005 0.971 0.005 0.974 0.005 0.974 0.005 1.000 0.000 0.949 0.006 Download
ECFP6 fingerprints 0.966 0.005 0.992 0.000 0.979 0.003 0.977 0.005 1.000 0.000 0.957 0.005 Download
  Download datasets
Positive dataset Negative dataset

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 E-mail: biomed@csu.edu.cn