Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (By similarity). Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth (PubMed:20079333).
Uniprot primary ID | Q99685 |
PDB ID | 3PE6 3HJU 3JWE 3JW8 4UUQ |
DrugBank ID | |
BioGrid ID | 116471 |
GuidetoPHARMACOLOGY ID | 1399 |
PharmGKB ID | PA30789 |
KEGG ID | hsa:11343 |
DIP ID | |
STRING ID | 9606.ENSP00000265052 |
IntAct ID | Q99685 |
DMDM | 47117287 |
BRENDA | 3.1.1.23 |
Reactome | R-HSA-426048 R-HSA-1482883 R-HSA-163560 |
SignaLink | |
BioCyc | |
Entrez Gene (Gene ID) | 11343 |
BindingDB | Q99685 |
Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FP2 fingerprints | 0.925 | 0.011 | 0.893 | 0.004 | 0.909 | 0.006 | 0.909 | 0.006 | 0.970 | 0.000 | 0.817 | 0.013 | Download |
Estate fingerprints | 0.777 | 0.008 | 0.905 | 0.007 | 0.841 | 0.006 | 0.830 | 0.007 | 0.938 | 0.004 | 0.690 | 0.012 | Download |
MACCS fingerprints | 0.926 | 0.005 | 0.920 | 0.012 | 0.923 | 0.007 | 0.922 | 0.006 | 0.967 | 0.005 | 0.840 | 0.012 | Download |
Daylight fingerprints | 0.879 | 0.009 | 0.815 | 0.000 | 0.847 | 0.005 | 0.850 | 0.007 | 0.890 | 0.000 | 0.695 | 0.008 | Download |
ECFP2 fingerprints | 0.969 | 0.003 | 0.921 | 0.008 | 0.945 | 0.005 | 0.947 | 0.005 | 0.988 | 0.004 | 0.890 | 0.007 | Download |
ECFP4 fingerprints | 0.974 | 0.005 | 0.936 | 0.007 | 0.955 | 0.005 | 0.955 | 0.005 | 0.990 | 0.000 | 0.907 | 0.008 | Download |
ECFP6 fingerprints | 0.971 | 0.003 | 0.967 | 0.007 | 0.969 | 0.003 | 0.970 | 0.005 | 0.990 | 0.000 | 0.937 | 0.008 | Download |
Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn