Target name

Q99685: Monoglyceride lipase


  Protein function

Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (By similarity). Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth (PubMed:20079333).

  Database links

Uniprot primary ID Q99685
PDB ID 3PE6 3HJU 3JWE 3JW8 4UUQ
DrugBank ID
BioGrid ID 116471
GuidetoPHARMACOLOGY ID 1399
PharmGKB ID PA30789
KEGG ID hsa:11343
DIP ID
STRING ID 9606.ENSP00000265052
IntAct ID Q99685
DMDM 47117287
BRENDA 3.1.1.23
Reactome R-HSA-426048 R-HSA-1482883 R-HSA-163560
SignaLink
BioCyc
Entrez Gene (Gene ID) 11343
BindingDB Q99685

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.925 0.011 0.893 0.004 0.909 0.006 0.909 0.006 0.970 0.000 0.817 0.013 Download
Estate fingerprints 0.777 0.008 0.905 0.007 0.841 0.006 0.830 0.007 0.938 0.004 0.690 0.012 Download
MACCS fingerprints 0.926 0.005 0.920 0.012 0.923 0.007 0.922 0.006 0.967 0.005 0.840 0.012 Download
Daylight fingerprints 0.879 0.009 0.815 0.000 0.847 0.005 0.850 0.007 0.890 0.000 0.695 0.008 Download
ECFP2 fingerprints 0.969 0.003 0.921 0.008 0.945 0.005 0.947 0.005 0.988 0.004 0.890 0.007 Download
ECFP4 fingerprints 0.974 0.005 0.936 0.007 0.955 0.005 0.955 0.005 0.990 0.000 0.907 0.008 Download
ECFP6 fingerprints 0.971 0.003 0.967 0.007 0.969 0.003 0.970 0.005 0.990 0.000 0.937 0.008 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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