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E-mail: biomed@csu.edu.cn
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Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration.
| Uniprot primary ID | Q99720 |
| PDB ID | |
| DrugBank ID | DB00652 DB00514 DB00321 DB00409 DB09014 DB00540 |
| BioGrid ID | 115569 |
| GuidetoPHARMACOLOGY ID | 2552 |
| PharmGKB ID | PA164725706 |
| KEGG ID | hsa:10280 |
| DIP ID | |
| STRING ID | 9606.ENSP00000277010 |
| IntAct ID | Q99720 |
| DMDM | 74752153 |
| BRENDA | |
| Reactome | |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 10280 |
| BindingDB | Q99720 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.890 | 0.000 | 0.810 | 0.000 | 0.850 | 0.000 | 0.851 | 0.003 | 0.920 | 0.000 | 0.700 | 0.000 | Download |
| Estate fingerprints | 0.879 | 0.003 | 0.821 | 0.003 | 0.850 | 0.000 | 0.854 | 0.005 | 0.930 | 0.000 | 0.701 | 0.003 | Download |
| MACCS fingerprints | 0.841 | 0.003 | 0.819 | 0.000 | 0.830 | 0.000 | 0.831 | 0.003 | 0.920 | 0.000 | 0.663 | 0.005 | Download |
| Daylight fingerprints | 0.670 | 0.000 | 0.830 | 0.005 | 0.750 | 0.000 | 0.728 | 0.004 | 0.830 | 0.000 | 0.500 | 0.000 | Download |
| ECFP2 fingerprints | 0.950 | 0.000 | 0.890 | 0.003 | 0.920 | 0.000 | 0.920 | 0.000 | 0.980 | 0.000 | 0.840 | 0.000 | Download |
| ECFP4 fingerprints | 0.960 | 0.000 | 0.922 | 0.005 | 0.941 | 0.003 | 0.942 | 0.004 | 0.981 | 0.003 | 0.888 | 0.004 | Download |
| ECFP6 fingerprints | 0.939 | 0.003 | 0.939 | 0.003 | 0.939 | 0.003 | 0.939 | 0.003 | 0.980 | 0.000 | 0.872 | 0.004 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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