Target name

Q99720: Sigma non-opioid intracellular receptor 1


  Protein function

Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration.

  Database links

Uniprot primary ID Q99720
PDB ID
DrugBank ID DB00652 DB00514 DB00321 DB00409 DB09014 DB00540
BioGrid ID 115569
GuidetoPHARMACOLOGY ID 2552
PharmGKB ID PA164725706
KEGG ID hsa:10280
DIP ID
STRING ID 9606.ENSP00000277010
IntAct ID Q99720
DMDM 74752153
BRENDA
Reactome
SignaLink
BioCyc
Entrez Gene (Gene ID) 10280
BindingDB Q99720

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.890 0.000 0.810 0.000 0.850 0.000 0.851 0.003 0.920 0.000 0.700 0.000 Download
Estate fingerprints 0.879 0.003 0.821 0.003 0.850 0.000 0.854 0.005 0.930 0.000 0.701 0.003 Download
MACCS fingerprints 0.841 0.003 0.819 0.000 0.830 0.000 0.831 0.003 0.920 0.000 0.663 0.005 Download
Daylight fingerprints 0.670 0.000 0.830 0.005 0.750 0.000 0.728 0.004 0.830 0.000 0.500 0.000 Download
ECFP2 fingerprints 0.950 0.000 0.890 0.003 0.920 0.000 0.920 0.000 0.980 0.000 0.840 0.000 Download
ECFP4 fingerprints 0.960 0.000 0.922 0.005 0.941 0.003 0.942 0.004 0.981 0.003 0.888 0.004 Download
ECFP6 fingerprints 0.939 0.003 0.939 0.003 0.939 0.003 0.939 0.003 0.980 0.000 0.872 0.004 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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