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E-mail: biomed@csu.edu.cn
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Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Inhibited by dipyridamole and dilazep (anticancer chemotherapeutics drugs).
| Uniprot primary ID | Q99808 |
| PDB ID | |
| DrugBank ID | DB00898 DB00987 DB01073 DB00642 DB01033 DB00441 DB00943 |
| BioGrid ID | 108344 |
| GuidetoPHARMACOLOGY ID | 1117 |
| PharmGKB ID | PA154 |
| KEGG ID | hsa:2030 |
| DIP ID | |
| STRING ID | 9606.ENSP00000360773 |
| IntAct ID | Q99808 |
| DMDM | 9296956 |
| BRENDA | |
| Reactome | R-HSA-83936 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 2030 |
| BindingDB | Q99808 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.955 | 0.005 | 0.991 | 0.000 | 0.973 | 0.005 | 0.970 | 0.000 | 0.990 | 0.000 | 0.942 | 0.009 | Download |
| Estate fingerprints | 0.953 | 0.005 | 0.931 | 0.000 | 0.942 | 0.004 | 0.942 | 0.004 | 0.990 | 0.000 | 0.881 | 0.006 | Download |
| MACCS fingerprints | 0.907 | 0.005 | 0.977 | 0.005 | 0.942 | 0.004 | 0.939 | 0.003 | 0.990 | 0.000 | 0.885 | 0.005 | Download |
| Daylight fingerprints | 0.867 | 0.005 | 0.985 | 0.000 | 0.926 | 0.005 | 0.920 | 0.000 | 0.980 | 0.000 | 0.856 | 0.005 | Download |
| ECFP2 fingerprints | 0.951 | 0.006 | 0.969 | 0.000 | 0.960 | 0.000 | 0.960 | 0.000 | 0.990 | 0.000 | 0.921 | 0.006 | Download |
| ECFP4 fingerprints | 0.950 | 0.007 | 0.982 | 0.003 | 0.966 | 0.005 | 0.966 | 0.005 | 0.990 | 0.000 | 0.929 | 0.009 | Download |
| ECFP6 fingerprints | 0.936 | 0.007 | 0.984 | 0.000 | 0.960 | 0.000 | 0.959 | 0.003 | 0.990 | 0.000 | 0.920 | 0.005 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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