Target name

Q99808: Equilibrative nucleoside transporter 1


  Protein function

Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Inhibited by dipyridamole and dilazep (anticancer chemotherapeutics drugs).

  Database links

Uniprot primary ID Q99808
PDB ID
DrugBank ID DB00898 DB00987 DB01073 DB00642 DB01033 DB00441 DB00943
BioGrid ID 108344
GuidetoPHARMACOLOGY ID 1117
PharmGKB ID PA154
KEGG ID hsa:2030
DIP ID
STRING ID 9606.ENSP00000360773
IntAct ID Q99808
DMDM 9296956
BRENDA
Reactome R-HSA-83936
SignaLink
BioCyc
Entrez Gene (Gene ID) 2030
BindingDB Q99808

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.955 0.005 0.991 0.000 0.973 0.005 0.970 0.000 0.990 0.000 0.942 0.009 Download
Estate fingerprints 0.953 0.005 0.931 0.000 0.942 0.004 0.942 0.004 0.990 0.000 0.881 0.006 Download
MACCS fingerprints 0.907 0.005 0.977 0.005 0.942 0.004 0.939 0.003 0.990 0.000 0.885 0.005 Download
Daylight fingerprints 0.867 0.005 0.985 0.000 0.926 0.005 0.920 0.000 0.980 0.000 0.856 0.005 Download
ECFP2 fingerprints 0.951 0.006 0.969 0.000 0.960 0.000 0.960 0.000 0.990 0.000 0.921 0.006 Download
ECFP4 fingerprints 0.950 0.007 0.982 0.003 0.966 0.005 0.966 0.005 0.990 0.000 0.929 0.009 Download
ECFP6 fingerprints 0.936 0.007 0.984 0.000 0.960 0.000 0.959 0.003 0.990 0.000 0.920 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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