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E-mail: biomed@csu.edu.cn
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G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia.
| Uniprot primary ID | Q99835 |
| PDB ID | 4QIN 4JKV 4QIM 4N4W 4O9R |
| DrugBank ID | DB01047 DB08828 |
| BioGrid ID | 112492 |
| GuidetoPHARMACOLOGY ID | 239 |
| PharmGKB ID | PA35968 |
| KEGG ID | hsa:6608 |
| DIP ID | DIP-34574N |
| STRING ID | 9606.ENSP00000249373 |
| IntAct ID | Q99835 |
| DMDM | 6226142 |
| BRENDA | |
| Reactome | R-HSA-373080 R-HSA-5620922 R-HSA-5610787 R-HSA-5635838 |
| SignaLink | Q99835 |
| BioCyc | |
| Entrez Gene (Gene ID) | 6608 |
| BindingDB | Q99835 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.913 | 0.005 | 0.947 | 0.004 | 0.930 | 0.000 | 0.930 | 0.000 | 0.980 | 0.000 | 0.866 | 0.005 | Download |
| Estate fingerprints | 0.800 | 0.005 | 0.806 | 0.009 | 0.803 | 0.005 | 0.803 | 0.005 | 0.899 | 0.003 | 0.611 | 0.009 | Download |
| MACCS fingerprints | 0.796 | 0.005 | 0.806 | 0.007 | 0.801 | 0.003 | 0.800 | 0.005 | 0.890 | 0.000 | 0.600 | 0.009 | Download |
| Daylight fingerprints | 0.838 | 0.006 | 0.984 | 0.003 | 0.911 | 0.003 | 0.903 | 0.005 | 0.970 | 0.000 | 0.832 | 0.006 | Download |
| ECFP2 fingerprints | 0.943 | 0.005 | 0.939 | 0.000 | 0.941 | 0.003 | 0.941 | 0.003 | 0.988 | 0.004 | 0.885 | 0.005 | Download |
| ECFP4 fingerprints | 0.946 | 0.005 | 0.994 | 0.003 | 0.970 | 0.000 | 0.970 | 0.000 | 0.990 | 0.000 | 0.938 | 0.004 | Download |
| ECFP6 fingerprints | 0.943 | 0.005 | 0.997 | 0.000 | 0.970 | 0.000 | 0.970 | 0.000 | 0.990 | 0.000 | 0.940 | 0.000 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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