Target name

Q99835: Smoothened homolog


  Protein function

G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia.

  Database links

Uniprot primary ID Q99835
PDB ID 4QIN 4JKV 4QIM 4N4W 4O9R
DrugBank ID DB01047 DB08828
BioGrid ID 112492
GuidetoPHARMACOLOGY ID 239
PharmGKB ID PA35968
KEGG ID hsa:6608
DIP ID DIP-34574N
STRING ID 9606.ENSP00000249373
IntAct ID Q99835
DMDM 6226142
BRENDA
Reactome R-HSA-373080 R-HSA-5620922 R-HSA-5610787 R-HSA-5635838
SignaLink Q99835
BioCyc
Entrez Gene (Gene ID) 6608
BindingDB Q99835

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.913 0.005 0.947 0.004 0.930 0.000 0.930 0.000 0.980 0.000 0.866 0.005 Download
Estate fingerprints 0.800 0.005 0.806 0.009 0.803 0.005 0.803 0.005 0.899 0.003 0.611 0.009 Download
MACCS fingerprints 0.796 0.005 0.806 0.007 0.801 0.003 0.800 0.005 0.890 0.000 0.600 0.009 Download
Daylight fingerprints 0.838 0.006 0.984 0.003 0.911 0.003 0.903 0.005 0.970 0.000 0.832 0.006 Download
ECFP2 fingerprints 0.943 0.005 0.939 0.000 0.941 0.003 0.941 0.003 0.988 0.004 0.885 0.005 Download
ECFP4 fingerprints 0.946 0.005 0.994 0.003 0.970 0.000 0.970 0.000 0.990 0.000 0.938 0.004 Download
ECFP6 fingerprints 0.943 0.005 0.997 0.000 0.970 0.000 0.970 0.000 0.990 0.000 0.940 0.000 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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