Target name

Q9GZU7: Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1


  Protein function

Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.

  Database links

Uniprot primary ID Q9GZU7
PDB ID 4YH1 2GHT 2GHQ 4YGY 1TA0 3L0C 3L0B 3L0Y 1T9Z 3PGL
DrugBank ID
BioGrid ID 121804
GuidetoPHARMACOLOGY ID
PharmGKB ID PA134938848
KEGG ID hsa:58190
DIP ID DIP-61246N
STRING ID 9606.ENSP00000273062
IntAct ID Q9GZU7
DMDM 17865510
BRENDA
Reactome
SignaLink Q9GZU7
BioCyc
Entrez Gene (Gene ID) 58190
BindingDB Q9GZU7

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.750 0.000 0.812 0.005 0.781 0.003 0.773 0.005 0.860 0.000 0.563 0.005 Download
Estate fingerprints 0.779 0.003 0.781 0.004 0.780 0.000 0.780 0.000 0.860 0.000 0.563 0.005 Download
MACCS fingerprints 0.757 0.005 0.755 0.005 0.756 0.005 0.757 0.005 0.830 0.000 0.513 0.005 Download
Daylight fingerprints 0.636 0.007 0.748 0.003 0.692 0.004 0.674 0.005 0.738 0.004 0.386 0.007 Download
ECFP2 fingerprints 0.852 0.006 0.830 0.005 0.841 0.003 0.847 0.005 0.920 0.000 0.688 0.004 Download
ECFP4 fingerprints 0.838 0.004 0.858 0.005 0.848 0.004 0.844 0.005 0.920 0.000 0.693 0.005 Download
ECFP6 fingerprints 0.813 0.005 0.851 0.008 0.832 0.004 0.829 0.003 0.912 0.004 0.664 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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