Target name

Q9H228: Sphingosine 1-phosphate receptor 5


  Protein function

Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells.

  Database links

Uniprot primary ID Q9H228
PDB ID
DrugBank ID DB08868
BioGrid ID 119793
GuidetoPHARMACOLOGY ID 279
PharmGKB ID PA162402378
KEGG ID hsa:53637
DIP ID
STRING ID 9606.ENSP00000328472
IntAct ID Q9H228
DMDM 62510663
BRENDA
Reactome R-HSA-419408 R-HSA-418594
SignaLink
BioCyc
Entrez Gene (Gene ID) 53637
BindingDB Q9H228

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.863 0.008 0.937 0.007 0.900 0.007 0.897 0.008 0.960 0.000 0.802 0.011 Download
Estate fingerprints 0.810 0.008 0.820 0.005 0.815 0.005 0.814 0.005 0.894 0.005 0.631 0.011 Download
MACCS fingerprints 0.815 0.005 0.907 0.004 0.861 0.006 0.854 0.005 0.909 0.003 0.726 0.010 Download
Daylight fingerprints 0.799 0.003 0.833 0.003 0.816 0.005 0.810 0.000 0.840 0.000 0.628 0.004 Download
ECFP2 fingerprints 0.940 0.007 0.974 0.006 0.957 0.005 0.955 0.005 0.989 0.003 0.913 0.011 Download
ECFP4 fingerprints 0.947 0.005 0.979 0.007 0.963 0.005 0.963 0.005 0.990 0.000 0.930 0.005 Download
ECFP6 fingerprints 0.939 0.006 0.993 0.000 0.966 0.005 0.966 0.005 0.988 0.004 0.935 0.007 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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