Target name

Q9H244: P2Y purinoceptor 12


  Protein function

Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Required for normal platelet aggregation and blood coagulation.

  Database links

Uniprot primary ID Q9H244
PDB ID 4PY0 4NTJ 4PXZ 1Y9C 1T78 1VZ1
DrugBank ID DB06209 DB00208 DB00758 DB08816 DB00374 DB01240
BioGrid ID 122309
GuidetoPHARMACOLOGY ID 328
PharmGKB ID PA134971947
KEGG ID hsa:64805
DIP ID DIP-61226N
STRING ID 9606.ENSP00000307259
IntAct ID
DMDM 21263835
BRENDA
Reactome R-HSA-418594 R-HSA-392170 R-HSA-417957
SignaLink
BioCyc
Entrez Gene (Gene ID) 64805
BindingDB Q9H244

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.795 0.005 0.985 0.000 0.890 0.000 0.880 0.000 0.950 0.000 0.800 0.000 Download
Estate fingerprints 0.839 0.003 0.841 0.006 0.840 0.000 0.840 0.000 0.908 0.004 0.681 0.006 Download
MACCS fingerprints 0.859 0.003 0.927 0.003 0.893 0.005 0.890 0.000 0.940 0.000 0.790 0.005 Download
Daylight fingerprints 0.725 0.005 0.985 0.000 0.855 0.005 0.834 0.005 0.937 0.005 0.734 0.005 Download
ECFP2 fingerprints 0.881 0.003 0.999 0.005 0.940 0.000 0.937 0.005 0.980 0.000 0.885 0.005 Download
ECFP4 fingerprints 0.890 0.000 0.990 0.000 0.940 0.000 0.940 0.000 0.990 0.000 0.891 0.003 Download
ECFP6 fingerprints 0.858 0.004 1.000 0.000 0.930 0.000 0.921 0.003 0.990 0.000 0.868 0.004 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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